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Related Experiment Videos

Isoniazid-induced fever.

J F Dasta, J A Prior, S Kurzrok

    Chest
    |February 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Isoniazid, a tuberculosis drug, can cause fever, nausea, and vomiting. These symptoms, resembling infection, resolved after stopping the medication, highlighting a potential diagnostic challenge.

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    Area of Science:

    • Pharmacology
    • Infectious Disease Management

    Background:

    • Tuberculosis (TB) treatment commonly utilizes isoniazid.
    • Isoniazid is initiated following a positive purified protein derivative (PPD) skin test.

    Observation:

    • A 56-year-old male developed fever (38-40°C), nausea, and vomiting after each dose of isoniazid.
    • The patient exhibited no signs of hypersensitivity, including rash, eosinophilia, elevated IgE, or abnormal liver function tests.

    Findings:

    • Discontinuation of isoniazid therapy led to the resolution of the patient's febrile reaction.
    • The observed symptoms were attributed to a direct effect of isoniazid, not a hypersensitivity reaction or infection.

    Implications:

    • Isoniazid can induce febrile reactions that may be misdiagnosed as an infectious process.
  • Clinicians should consider drug-induced fever in patients on isoniazid presenting with unexplained elevated temperatures.