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Updated: May 21, 2026
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Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
Published on: January 29, 2016
Prescribing Resistance Training in Multiple Sclerosis: A Systematic Review and Meta-Analysis of Randomized Controlled
Fu-An Yang1,2, Hung-Chou Chen3,4, Pei-Jyuan Wu1
1Department of Physical Medicine and Rehabilitation, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
Summary
Resistance training significantly improves strength, walking, and quality of life for multiple sclerosis patients. Programs over 20 sessions show greater functional benefits and are safe for ambulatory individuals.
Area of Science:
- Neurology
- Rehabilitation Medicine
- Exercise Science
Background:
- Resistance training shows promise for multiple sclerosis (MS) management.
- Optimal dosage and clinical protocols for resistance training in MS are not well-defined.
Purpose of the Study:
- To assess resistance training effects on strength, walking, fatigue, and quality of life in MS.
- To develop a practical frequency, intensity, time, and type (FITT) framework for resistance training in MS.
Main Methods:
- Systematic review and meta-analysis of 18 randomized controlled trials.
- Comparison of resistance training interventions against usual care in ambulatory individuals with MS.
Main Results:
- Resistance training significantly enhanced knee extensor strength, walking speed, endurance, and functional mobility.
- Improvements were observed in fatigue levels and quality of life.
- A dose-response relationship was noted, with programs exceeding 20 sessions yielding more consistent functional and quality-of-life benefits.
Conclusions:
- Resistance training is an effective and safe therapeutic option for ambulatory individuals with MS.
- While strength improvements are rapid, longer programs (over 20 sessions) are linked to more substantial functional and quality-of-life gains.
