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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

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[Acute Measles Encephalitis]

Hiroya Kuwahara1

  • 1Department of Neurology and Neurological Science, Graduate School, Institute of Science Tokyo.

Brain and Nerve = Shinkei Kenkyu No Shinpo
|May 19, 2026
PubMed

Insights

Measles is a highly infectious illness. Acute measles encephalitis is a rare, severe complication that can be fatal or lead to lasting neurological issues, emphasizing the need for vaccination.

Area of Science:

  • Infectious Diseases
  • Neurology
  • Public Health

Background:

  • Measles is an acute, highly infectious viral illness.
  • Complications include pneumonia and encephalitis, with acute measles encephalitis being a rare but severe neurological sequela.
  • No specific antiviral treatment exists; management is supportive.

Purpose of the Study:

  • To summarize the clinical presentation and outcomes of acute measles encephalitis.
  • To highlight the importance of vaccination in preventing measles and its severe complications.
  • To discuss strategies for maintaining measles control.

Main Methods:

  • Review of clinical characteristics of acute measles encephalitis.
  • Analysis of epidemiological data regarding measles incidence and vaccination coverage.
  • Discussion of current prevention strategies.

Main Results:

  • Acute measles encephalitis presents with fever, altered consciousness, seizures, and neurological deficits.
  • The condition has a high mortality rate, with survivors often experiencing neurological deficits.
  • Japan's low measles incidence is attributed to high vaccination coverage.

Conclusions:

  • Acute measles encephalitis is a critical complication of measles infection.
  • Supportive care is the mainstay of management.
  • Maintaining high two-dose vaccination coverage and targeting unvaccinated adults are essential for measles prevention.

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