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Related Experiment Video

Updated: May 21, 2026

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

Published on: April 17, 2013

Diffuse thyroid metastasis from oropharyngeal squamous cell carcinoma.

Aymen Bahsoun¹, Aziz Farhat², Sami Issa³

¹Radiology, University of Michigan Michigan Medicine, Ann Arbor, Michigan, USA alexanderdream98@gmail.com.

BMJ Case Reports

|May 19, 2026

Summary

Thyroid metastasis from oropharyngeal squamous cell carcinoma is rare. This case highlights the importance of considering unusual metastatic sites in advanced head and neck cancers, particularly those linked to human papillomavirus.

Keywords:

Head and neck cancer Human papilloma virus Radiology Thyroid Gland

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Last Updated: May 21, 2026

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

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Spontaneous Murine Model of Anaplastic Thyroid Cancer

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

Area of Science:

Oncology
Head and Neck Surgery
Pathology

Background:

Thyroid metastasis (TM) from oropharyngeal squamous cell carcinoma (OPSCC) is exceptionally rare.
The thyroid's microenvironment typically does not support metastatic spread, making such occurrences noteworthy.

Purpose of the Study:

To report a rare case of diffuse thyroid metastasis from p16-positive tonsillar squamous cell carcinoma.
To emphasize the importance of considering uncommon metastatic sites in advanced OPSCC, especially HPV-related cases.

Main Methods:

Case report of a male patient in his late 70s with p16-positive tonsillar SCC.
Diagnostic workup included assessment for dysphonia, weight loss, cervical lymphadenopathy, and fine needle aspiration (FNA) for thyroid involvement.

Main Results:

The patient presented with advanced SCC of the tonsil and bilateral cervical lymphadenopathy.
Fine needle aspiration confirmed diffuse thyroid metastasis with p16-positive SCC.

Conclusions:

Advanced OPSCC can metastasize to unusual sites like the thyroid gland.
Comprehensive diagnostic evaluation is crucial for identifying uncommon metastatic patterns, guiding tailored treatment strategies for rare presentations.