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Associations of Blood Soluble Fas and IGF-I with Risk of Hemorrhagic Stroke: The Circulatory Risk Communities Study

Kenichi Ariyada1, Tomoko Sankai1, Kazumasa Yamagishi2,3

  • 1Department of Public Health Medicine, Institute of Medicine, and Health Services Research and Development Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8577, Ibaraki, Japan.

Translational Stroke Research
|May 19, 2026
PubMed

Insights

Higher insulin-like growth factor-I levels were associated with a lower risk of hemorrhagic stroke. This study investigated growth factors and stroke risk, finding a significant inverse association for insulin-like growth factor-I.

Area of Science:

  • Cardiovascular Research
  • Neurology
  • Endocrinology

Background:

  • Limited evidence exists on the prospective association between apoptosis-related factors, growth factors, and hemorrhagic stroke.
  • Previous research focused more on general cardiovascular diseases than specific stroke types.

Purpose of the Study:

  • To investigate the prospective association between serum levels of soluble Fas and insulin-like growth factor-I (IGF-I) and the risk of hemorrhagic stroke.
  • To examine these associations for both intracerebral hemorrhage and subarachnoid hemorrhage.

Main Methods:

  • A nested case-control study was conducted within the Circulatory Risk in Communities Study cohort in Japan.
  • Serum levels of soluble Fas and IGF-I were measured in 98 hemorrhagic stroke cases and 196 matched controls.
  • Conditional logistic regression analyses were used to calculate odds ratios for hemorrhagic stroke risk.

Main Results:

  • A 1-standard deviation increase in insulin-like growth factor-I (IGF-I) was associated with a reduced risk of total hemorrhagic stroke (OR, 0.61; 95% CI, 0.41-0.89).
  • The inverse association between IGF-I and hemorrhagic stroke risk was observed for both subarachnoid hemorrhage (OR, 0.53; 95% CI, 0.28-0.98) and intracerebral hemorrhage (OR, 0.62; 95% CI, 0.37-1.04).
  • No significant association was found between soluble Fas levels and total hemorrhagic stroke risk (OR, 0.93; 95% CI, 0.66-1.32).

Conclusions:

  • Higher serum levels of insulin-like growth factor-I are associated with a decreased risk of hemorrhagic stroke.
  • These findings suggest a potential protective role of IGF-I against hemorrhagic stroke.
Abstract

Keywords:
Cohort studyHemorrhagic strokeIGF-IIntracerebral hemorrhageSoluble FasSubarachnoid hemorrhage

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