Decidual aging in recurrent pregnancy Loss: from regulating networks to therapeutic interventions

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Platform for Quantitative Detection of Endometrial Immune Cells Based on Immunohistochemistry and Digital Image Analysis
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Yu Liu1, Wenyan Shi1, Zhonglin Jiang2

  • 1Department of Obstetrics and Gynecology, Binzhou Medical University Hospital, Shandong Medical and Pharmaceutical University, Binzhou City, China.

Npj Aging
|May 19, 2026
PubMed

.The uterine decidua is a key component of the maternal-fetal interface, and its senescence may be an important contributing factor to recurrent pregnancy loss (RPL). Decidual senescence disrupts gestational homeostasis via cell cycle arrest, immune imbalance, and metabolic reprogramming, thereby potentially contributing to RPL. This review offers a new paradigm for understanding RPL etiology, with significant clinical value for improving reproductive outcomes.

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