TaRGET II Data Portal: a multi-omics resource for environmental toxicant studies in mice

The Toxicant Exposures and Responses by Genomic and Epigenomic Regulators of Transcription (TaRGET) program is a multiphase program that aims to understand how environmental factors contribute to disease susceptibility using toxicant-exposed mouse models. Here, we present the TaRGET II Data Portal ( https://data.targetepigenomics.org/ ), a comprehensive repository of multi-omics datasets generated from mice exposed to a range of environmental toxicants, including arsenic (As), lead (Pb), bisphenol A (BPA), tributyltin (TBT), di(2-ethylhexyl) phthalate (DEHP), tetrachlorodibenzo-p-dioxin (TCDD), and ambient air pollution (PM2.5). Epigenomic profiling assays capturing alterations in chromatin accessibility, DNA methylation, gene expression, and histone modifications were produced across multiple research centers, subjected to rigorous quality control, and processed using standardized pipelines. The portal currently hosts 3,612 datasets spanning multiple tissues and genomic assays, collected at four developmental and exposure time points: 3, 5, 20, and 40 weeks. The portal offers an efficient way to browse, search, visualize, and download relevant datasets and associated metadata, serving as a key resource for studying the impact of environmental toxicant exposures on disease susceptibility for the broader scientific community.