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Metabolic parameter variability, brain structure, perfusion, and cognition: a population-based study.

Xiaoshuai Li1, Xuejia Li2, Mengmeng Bai3

  • 1Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.

Alzheimer'S Research & Therapy
|May 20, 2026
PubMed
Summary
This summary is machine-generated.

Metabolic parameter variability is linked to cognitive decline. Reduced white matter blood flow and gray matter volume mediate this association, impacting cognitive performance.

Keywords:
Brain volumeCerebral blood flowCoefficient of variationCognitive functionMediation analysesMetabolic parameter variability

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Area of Science:

  • Neuroscience
  • Metabolic Health
  • Cognitive Science

Background:

  • Metabolic instability is known to impact cognitive function, but the underlying mechanisms remain unclear.
  • This study investigates the link between variability in metabolic parameters and cognitive outcomes.

Purpose of the Study:

  • To examine the association between metabolic parameter variability, brain volume, and cerebral blood flow (CBF).
  • To determine if CBF and brain volume mediate the relationship between metabolic variability and cognitive performance.

Main Methods:

  • Prospective cohort study (Kailuan study, 2006-2020) including 1894 participants.
  • Metabolic parameter variability (systolic blood pressure, glucose, LDL, BMI) assessed using coefficient of variation (CV).
  • Brain MRI and Montreal Cognitive Assessment (MoCA) performed; generalized linear regression and mediation analyses used.

Main Results:

  • High metabolic variability correlated with reduced CBF in total brain, white matter, temporal lobe, and hippocampus.
  • Increased metabolic variability was associated with decreased gray matter and temporal lobe volume.
  • Metabolic variability linked to lower MoCA scores; this association was mediated by white matter CBF, gray matter volume, and temporal lobe volume.

Conclusions:

  • Reduced total white matter CBF, gray matter volume, and temporal lobe volume mediate the link between metabolic variability and cognitive decline.
  • Total white matter CBF demonstrated the most significant mediating effect in this relationship.