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Related Experiment Video

Updated: May 21, 2026

Laparoscopic Repair of Para-Esophageal Hernia Using Absorbable Biosynthetic Mesh
10:52

Laparoscopic Repair of Para-Esophageal Hernia Using Absorbable Biosynthetic Mesh

Published on: September 11, 2021

ROS-Responsive Dynamic Hydrogel for Gastric Perforation Repair.

Jiaying Liu1,2, Renjie Li2, Qingyun Chu2

  • 1Department of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, P. R. China.

Macromolecular Rapid Communications
|May 20, 2026
PubMed
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This summary is machine-generated.

This study introduces a novel dynamic hydrogel for gastric perforation repair. The hydrogel seals effectively and releases an antioxidant on-demand, promoting faster healing by reducing oxidative stress.

Area of Science:

  • Biomaterials Science
  • Gastroenterology
  • Drug Delivery Systems

Background:

  • Gastric perforation repair requires advanced materials addressing peristalsis and oxidative stress.
  • Existing treatments face challenges in maintaining seal integrity and managing the wound microenvironment.

Purpose of the Study:

  • To develop a reactive oxygen species (ROS)-responsive dynamic hydrogel for effective gastric perforation repair.
  • To achieve robust sealing, controlled drug release, and modulation of the wound microenvironment.

Main Methods:

  • Fabrication of a dynamic hydrogel (PEG-PL-TA1) using imine-crosslinked networks and a ROS-cleavable tannic acid-2-formylphenylboronic acid complex.
  • In situ gelation, tissue adhesion, and burst pressure assessments.
  • In vivo evaluation of the hydrogel in a rat gastric perforation model.
Keywords:
ROS‐responseanti‐oxidationcontrolled drug releasedynamic hydrogelgastric perforation repair

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Last Updated: May 21, 2026

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The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
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Published on: October 7, 2016

Main Results:

  • The PEG-PL-TA1 hydrogel demonstrated rapid gelation (∼64 s), strong tissue adhesion (∼25.7 kPa), and high burst pressure (∼128.8 mmHg).
  • ROS-triggered release of tannic acid (TA) provided antioxidant protection to gastric cells.
  • In vivo studies showed accelerated perforation repair due to synergistic sealing and oxidative stress alleviation.

Conclusions:

  • The developed dynamic hydrogel offers a promising strategy for gastric perforation treatment.
  • The hydrogel effectively seals defects, releases antioxidants on demand, and promotes wound healing by managing oxidative stress and immune balance.