Related Experiment Video
Updated: May 21, 2026
10:52
Laparoscopic Repair of Para-Esophageal Hernia Using Absorbable Biosynthetic Mesh
Published on: September 11, 2021
ROS-Responsive Dynamic Hydrogel for Gastric Perforation Repair
Jiaying Liu1,2, Renjie Li2, Qingyun Chu2
1Department of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, P. R. China.
Macromolecular Rapid Communications
|May 20, 2026
Summary
This study introduces a novel dynamic hydrogel for gastric perforation repair. The hydrogel seals effectively and releases an antioxidant on-demand, promoting faster healing by reducing oxidative stress.
Area of Science:
- Biomaterials Science
- Gastroenterology
- Drug Delivery Systems
Background:
- Gastric perforation repair requires advanced materials addressing peristalsis and oxidative stress.
- Existing treatments face challenges in maintaining seal integrity and managing the wound microenvironment.
Purpose of the Study:
- To develop a reactive oxygen species (ROS)-responsive dynamic hydrogel for effective gastric perforation repair.
- To achieve robust sealing, controlled drug release, and modulation of the wound microenvironment.
Main Methods:
- Fabrication of a dynamic hydrogel (PEG-PL-TA1) using imine-crosslinked networks and a ROS-cleavable tannic acid-2-formylphenylboronic acid complex.
- In situ gelation, tissue adhesion, and burst pressure assessments.
- In vivo evaluation of the hydrogel in a rat gastric perforation model.
Main Results:
- The PEG-PL-TA1 hydrogel demonstrated rapid gelation (∼64 s), strong tissue adhesion (∼25.7 kPa), and high burst pressure (∼128.8 mmHg).
- ROS-triggered release of tannic acid (TA) provided antioxidant protection to gastric cells.
- In vivo studies showed accelerated perforation repair due to synergistic sealing and oxidative stress alleviation.
Conclusions:
- The developed dynamic hydrogel offers a promising strategy for gastric perforation treatment.
- The hydrogel effectively seals defects, releases antioxidants on demand, and promotes wound healing by managing oxidative stress and immune balance.
