MRI Based Radiomics as an Imaging Biomarker for Locally Advanced Carcinoma Rectum: Predicting Tumor Response...

Patients with locally advanced rectal cancer show variable responses to neoadjuvant chemoradiotherapy (NACTRT), making early prediction of treatment response clinically important. Radiomics and machine learning may offer a potential non-invasive imaging biomarker to identify patients who are more likely to respond to treatment.

We investigated a machine learning-based radiomic approach to predict tumor response (TR) to NACTRT in patients with adenocarcinoma of the rectum from baseline and post-NACTRT magnetic resonance imaging (MRI).

One hundred patients with locally advanced rectal cancer, who underwent pre- and post-treatment MRI after NACTRT were included in the study after approval from the institutional ethics committee. One hundred twenty-four radiomic features were extracted using the TexRad softwareTm, from pre- and post-treatment T2W MRI, which included first-order, GLCM, and shape features. Features were selected by the recursive feature elimination (RFE) algorithm. Five machine learning classifiers-support vector machine (SVM), random forest (RF), gradient boost (GB), Naive Bayes (NB) and AdaBoost (AB) classifiers were used to develop a prediction model for predicting TR.

Five radiomic features were selected using for TR using RFE using RF algorithm. The RF model with 10-fold internal cross-validation performed the best for predicting TR. The predictive performance of the RF model for TR was found to be AUC: 0.79 ± 0.15, accuracy: 0.72 ± 0.12, and precision: 0.77 ± 0.10 for the test cohort respectively.

RF classifier based radiomic model provided a non-invasive method to predict TR in patients of carcinoma rectum undergoing NACTRT treatment. The predictive potential of the radiomic features further requires validation in a larger cohort of patients in a multicentric study for clinical translation.