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Updated: May 21, 2026
Revealing the Ferroptotic Phenotype of Medulloblastoma
Published on: March 15, 2024
Discovery of Quebrachamine-like Indole Alkaloids with Ferroptosis Inhibitory Activity from Catharanthus roseus Using
Feng Qin1,2, Fan-Fan Wang2, Jianan Guo3
1Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China.
Abstract:
Velbanamines A-L (1-12), 12 novel quebrachamine-like indole alkaloids, were isolated from Catharanthus roseus L. (G.) Don under the guidance of HSQC-based DeepSAT. Their structures and absolute configurations were elucidated unambiguously by comprehensive spectroscopic analyses, single-crystal X-ray diffraction analysis, and electronic circular dichroism (ECD) calculations and computational calculations. Structurally, compound 1 features a unique skeleton with a 6/5/8/5 tetracyclic system. The plausible biosynthetic pathway of 1 was also proposed. In addition, all compounds demonstrated anti-ferroptotic activity in cardiomyocytes. Among them, Compound 8 was the most potent (IC50 = 0.12 ± 0.01 μM), and also suppressed lipid ROS accumulation and regulated ferroptosis-related proteins.
