Related Experiment Video
Updated: May 21, 2026
04:41
Vascular Organoid Generation from Human-Induced Pluripotent Stem Cells
Published on: December 13, 2024
Disease modelling with in vitro vascularised organoids
Chloe Kan1,2, Lu Liu1,2, Rio Sugimura1,2
1School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Disease Models & Mechanisms
|May 20, 2026
Summary
Vascularised organoids, 3D stem cell models with blood vessels, advance disease modeling. This review compares methods for creating these complex organoids, highlighting their potential for mimicking human physiology.
Area of Science:
- Biotechnology
- Developmental Biology
- Tissue Engineering
Background:
- Organoids are advanced 3D stem cell models replicating human tissue microenvironments.
- Vasculature is crucial for biological processes, driving the need for vascularised organoids.
- Vascularised organoids offer powerful tools for drug screening and disease modeling.
Purpose of the Study:
- To review current methods for fabricating vascularised organoids.
- To compare the advantages and limitations of different vasculature fabrication approaches.
- To discuss the application of vascularised organoids in disease modeling and future directions.
Main Methods:
- Co-culture with vascular endothelial cells
- Assembloids
- Co-differentiation
- Genetic engineering
- 3D bioprinting
- Organ-on-a-chip systems
Main Results:
- A comprehensive overview of existing vasculature fabrication techniques for organoids.
- Comparative analysis of fabrication methods, detailing their pros and cons.
- Exploration of vascularised organoids' utility in modeling various human diseases.
Conclusions:
- Vascularised organoids represent a significant advancement in mimicking human physiological conditions.
- These models hold great promise as clinically relevant tools for disease research and drug development.
- Further research is needed to overcome current challenges and fully realize the potential of vascularised organoids.
