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Associations Between Metabolic Dysregulation and Stage B Heart Failure in Hispanic Populations

Miryoung Lee1, Soumya Patnaik2, Emma Molina1

  • 1School of Public Health, Department of Epidemiology, Brownsville Campus, University of Texas Health Science Center at Houston, One West University Blvd, Brownsville, Texas, USA.

Echocardiography (Mount Kisco, N.Y.)
|May 20, 2026
PubMed

Insights

Subclinical heart abnormalities like left ventricular remodeling and diastolic dysfunction are common in asymptomatic Hispanics/Latinos. Cardiometabolic risk factors, including obesity and hypertension, contribute to these early cardiac issues.

Area of Science:

  • Cardiology
  • Preventive Medicine
  • Public Health

Background:

  • Left ventricular structural abnormalities (concentric remodeling [CR] or hypertrophy [LVH]) and diastolic dysfunction (LVDD) are key to diastolic heart failure (HF).
  • These conditions are linked to prevalent cardiometabolic risk factors in Mexican Americans.

Purpose of the Study:

  • To determine the prevalence of subclinical LV structural abnormalities (LVH or CR) and LVDD (Stage B HF) in asymptomatic Hispanics/Latinos.
  • To examine the cardiometabolic determinants of these cardiac abnormalities.

Main Methods:

  • 1128 participants from the Cameron County Hispanic Cohort underwent evaluation for cardiac structure and function via echocardiography.
  • Demographic, metabolic, and body composition data, including visceral fat (dual-energy x-ray absorptiometry), were collected.
  • Weighted logistic regression analyses adjusted for covariates.

Main Results:

  • High prevalence rates observed for LV structural abnormalities (55.9%) and LVDD (19.6%).
  • Adjusted models linked age, BMI, hypertension, and metabolic syndrome to CR, LVH, or LVDD.
  • In women, increased visceral adiposity and metabolic syndrome correlated with CR or LVH.

Conclusions:

  • Stage B HF is highly prevalent in this Hispanic/Latino cohort.
  • Visceral adiposity, metabolic syndrome, and hypertension show independent, differential relationships with early cardiac abnormalities.
  • Targeted interventions are crucial for preventing progression to symptomatic heart failure.
Abstract

Keywords:
Hispanicsdiabetesdiastolic dysfunctionleft ventricular hypertrophymetabolic syndromevisceral adipose tissue

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