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Updated: May 21, 2026

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
10:36

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer

Published on: March 17, 2016

Selective Induction of Estrogen Receptor-Dependent Stress Signaling as a Therapeutic Strategy in Resistant Breast

Anna C Renner1, Robert B Kargbo2

  • 1North Dakota State University, Fargo, North Dakota 58108-6050, United States.

ACS Medicinal Chemistry Letters
|May 20, 2026
PubMed

Insights

New small molecules activate estrogen receptor alpha (ERα) to induce a targeted cancer cell death pathway. This approach offers a novel strategy to overcome endocrine resistance in ERα-positive breast cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Drug Discovery

Background:

  • Estrogen receptor alpha (ERα) is a key target in hormone receptor-positive breast cancer.
  • Acquired resistance to endocrine therapies limits long-term patient benefit.

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