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Functional Cardiac Imaging in Zebrafish Embryos Using Standard Microscopy and Video Analysis: Applications in Environmental and Biomedical Research

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Zebrafish in Cardiovascular Disease Research: from Model to Application.

Ranran Wang¹, Qian Zhang¹, Shuhui Zhang¹

¹Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu 610106, China.

International Journal of Biological Sciences

|May 20, 2026

Summary

Zebrafish offer unique advantages for cardiovascular disease (CVD) research, enabling high-throughput screening and modeling of human heart conditions. Their genetic similarity and regenerative capacity accelerate drug discovery and therapeutic development for CVDs.

Keywords:

Cardiovascular disease Disease modeling Drug discovery Heart High-throughput screening Zebrafish

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Last Updated: May 21, 2026

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Published on: February 9, 2022

Area of Science:

Comparative biology
Cardiovascular research
Model organism development

Background:

Cardiovascular diseases (CVDs) are a leading global health concern with complex pathophysiology.
Traditional mammalian and in vitro models have limitations in fully recapitulating CVDs.
Zebrafish present a promising alternative model system for studying cardiovascular disorders.

Purpose of the Study:

To highlight the advantages of zebrafish in cardiovascular disease (CVD) research.
To demonstrate the utility of zebrafish in modeling human CVDs and facilitating drug discovery.
To underscore the value of zebrafish in advancing therapeutic development for CVDs.

Main Methods:

Utilizing zebrafish for high-throughput screening due to their small size, high fecundity, and rapid development.
Employing embryonic transparency for real-time, noninvasive imaging of cardiac processes.
Leveraging genetic homology and facile genetic manipulation for modeling cardiovascular disorders and regeneration studies.

Main Results:

Zebrafish models have successfully recapitulated key features of human CVDs, aiding mechanistic investigations.
The transparency and genetic tractability of zebrafish enable efficient phenotypic screening.
Zebrafish have proven valuable in early-stage drug discovery and cardiotoxicity assessment.

Conclusions:

Zebrafish offer a powerful, cost-efficient platform for cardiovascular research, combining genetic tractability, phenotypic fidelity, and screening efficiency.
Their utility extends from mechanistic studies and pathway identification to drug discovery and cardiotoxicity assessment.
Zebrafish represent a significant advancement in developing new therapies for cardiovascular diseases.