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Updated: May 21, 2026

Methods to Study Epithelial Transport Protein Function and Expression in Native Intestine and Caco-2 Cells Grown in 3D
11:27

Methods to Study Epithelial Transport Protein Function and Expression in Native Intestine and Caco-2 Cells Grown in 3D

Published on: March 16, 2017

System L Amino Acid Transporter LAT1 is required for Mouse Intestinal Epithelial Homeostasis.

Lingyu Bao1, Zhaoyi Peng1,2, Bingyin Shi3

  • 1Section on Molecular Morphogenesis, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, MD, USA.

International Journal of Biological Sciences
|May 20, 2026
PubMed
Summary

System L amino acid transporter 1 (slc7a5) is crucial for maintaining intestinal homeostasis. Inducible knockout of slc7a5 in adult mice reduces Paneth cells and increases crypt cell proliferation, suggesting an indirect role in cell regulation.

Keywords:
Paneth cell, stem cellamino acid transporter slc7a5intestinemTORC1 signaling pathwayorgan homeostasis

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