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Probable Catastrophic Antiphospholipid Syndrome Overlapping Hematological Abnormalities: A Case Report.
Faseeh Ullah1, Maryam Tariq1, Marwa Farzand1
1Aziz Fatimah Medical and Dental College Faisalabad Pakistan.
Clinical Case Reports
|May 20, 2026
Summary
A postpartum woman developed catastrophic antiphospholipid syndrome (CAPS) with multiple organ failures. Prompt treatment with transfusions and plasmapheresis led to substantial recovery, highlighting the importance of early intervention for this rare condition.
Area of Science:
- Obstetrics and Gynecology
- Hematology
- Rheumatology
Background:
- Catastrophic Antiphospholipid Syndrome (CAPS) is a rare, life-threatening condition characterized by rapid, widespread thrombotic events.
- Postpartum women are at increased risk for thrombotic complications.
- Early diagnosis and aggressive management are crucial for improving outcomes in CAPS.
Purpose of the Study:
- To report a case of postpartum CAPS presenting with severe multi-organ involvement.
- To highlight the diagnostic challenges and treatment strategies for this critical condition.
Main Methods:
- A case report of a young South Asian woman presenting four weeks post-miscarriage.
- Clinical presentation included fever, jaundice, edema, neurological deficits, anemia, thrombocytopenia, proteinuria, hematuria, splenic infarct, and cerebral venous sinus thrombosis.
- Diagnosis was supported by positive beta-2 glycoprotein IgG and lupus anticoagulant.
Main Results:
- The patient exhibited a constellation of severe symptoms indicative of widespread thrombosis and organ damage.
- Laboratory findings and clinical signs strongly suggested antiphospholipid syndrome.
- Treatment with transfusions and plasmapheresis resulted in significant clinical improvement.
Conclusions:
- This case underscores the potential for catastrophic antiphospholipid syndrome to manifest in the postpartum period with diverse and severe clinical features.
- Aggressive management, including plasmapheresis, can lead to favorable outcomes even in severe cases of postpartum CAPS.
- Increased awareness and timely intervention are vital for managing this obstetric emergency.
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