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Related Concept Videos

Social Relationships and Well-Being01:30

Social Relationships and Well-Being

The significance of social relationships in psychological well-being is a well-established area of inquiry within social psychology. Research consistently demonstrates that the presence of meaningful, supportive relationships enhances emotional health, while the absence or deterioration of such connections can contribute to psychological distress. Relationships serve as a foundation for emotional support, identity, and social belonging, all of which are critical to an individual’s overall...
Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Long-term Depression01:03

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over time, all...
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Longitudinal Research02:20

Longitudinal Research

Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
Depression: Overview01:18

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...

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Related Experiment Video

Updated: May 21, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

Does alleviating depression reduce loneliness? A longitudinal study.

Nishtha Chaurasiya1, Debasish Basu1, Swapnajeet Sahoo1

  • 1Department of Psychiatry, Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Indian Journal of Psychiatry
|May 20, 2026
PubMed
Summary
This summary is machine-generated.

Loneliness is common in depression and persists even after symptoms improve. Addressing loneliness directly may be crucial for better treatment outcomes in depressive disorders.

Keywords:
Depressionlonelinesssocial connectednesssocial relationships

Related Experiment Videos

Last Updated: May 21, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

Area of Science:

  • Psychiatry
  • Psychology
  • Clinical Research

Background:

  • Loneliness significantly impacts depression outcomes.
  • The trajectory and factors associated with loneliness during depression recovery are not well understood.

Purpose of the Study:

  • To investigate the prevalence, course, and psychosocial/clinical correlates of loneliness in patients with depression.
  • To utilize a longitudinal design for comprehensive analysis.

Main Methods:

  • A naturalistic longitudinal study involving 110 patients with a current depressive episode.
  • Assessments at baseline and 3-month follow-up included multiple validated scales for depression, loneliness, social support, sleep quality, quality of life, and suicidality.
  • Statistical analyses included univariate and multivariate regression to identify predictors of loneliness.

Main Results:

  • High baseline loneliness (94.5%) decreased but remained significant at follow-up (58.2%).
  • Loneliness persisted in 45.7% of patients who achieved depressive symptom remission.
  • Loneliness correlated with depression severity, social connectedness, social support, sleep quality, quality of life, and suicidality.

Conclusions:

  • Loneliness is highly prevalent in depression and often endures despite symptom improvement.
  • Loneliness may require distinct therapeutic targets and focused psychosocial interventions.
  • Social connectedness and quality of life in social relationships are key predictors of persistent loneliness.