Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neuron Structure01:30

Neuron Structure

Neurons are the main type of cell in the nervous system that generate and transmit electrochemical signals. They primarily communicate with each other using neurotransmitters at specific junctions called synapses. Neurons come in many shapes that often relate to their function, but most share three main structures: an axon and dendrites that extend out from a cell body.
Structure and Function of Neurons
The neuronal cell body—the soma— houses the nucleus and organelles vital to cellular...
Glial Cells01:04

Glial Cells

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Perinatal brain developmental transition revealed by transcriptomic and proteomic analyses of Bama miniature pigs.

Nature communications·2026
Same author

SEPAR enables spatial metagene discovery and associated molecular pattern characterization in spatial transcriptomics and multi-omics datasets.

Communications biology·2025
Same author

Direct and indirect neurogenesis from radial glial progenitor cell clones in the mouse neocortex.

The EMBO journal·2025
Same author

MultiGATE: integrative analysis and regulatory inference in spatial multi-omics data via graph representation learning.

Nature communications·2025
Same author

Cortical arealization of interneurons defines shared and distinct molecular programs in developing human and macaque brains.

Nature communications·2025
Same author

Exploring PDE5A upregulation in bipolar disorder: insights from single-nucleus RNA sequencing of human basal ganglia.

Translational psychiatry·2024

Related Experiment Video

Updated: May 21, 2026

Synaptic Microcircuit Modeling with 3D Cocultures of Astrocytes and Neurons from Human Pluripotent Stem Cells
08:48

Synaptic Microcircuit Modeling with 3D Cocultures of Astrocytes and Neurons from Human Pluripotent Stem Cells

Published on: August 16, 2018

The Role of Astrocyte-Neuron Interactions in Shaping Neuronal Maturation during Human Brain Development.

Manman Zhao1,2, Ying Zhu1

  • 1State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science and Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200032, China.

Computational and Structural Biotechnology Journal
|May 20, 2026
PubMed
Summary

Human brain development involves significant gene expression changes, especially in glial cells supporting neuronal maturation. This study reveals how astrocyte subtypes influence human brain development and circuit formation, offering insights into neurodevelopmental disorders.

More Related Videos

Investigation of Spatial Interaction Between Astrocytes and Neurons in Cleared Brains
05:17

Investigation of Spatial Interaction Between Astrocytes and Neurons in Cleared Brains

Published on: March 31, 2022

Related Experiment Videos

Last Updated: May 21, 2026

Synaptic Microcircuit Modeling with 3D Cocultures of Astrocytes and Neurons from Human Pluripotent Stem Cells
08:48

Synaptic Microcircuit Modeling with 3D Cocultures of Astrocytes and Neurons from Human Pluripotent Stem Cells

Published on: August 16, 2018

Investigation of Spatial Interaction Between Astrocytes and Neurons in Cleared Brains
05:17

Investigation of Spatial Interaction Between Astrocytes and Neurons in Cleared Brains

Published on: March 31, 2022

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Genomics

Background:

  • The human brain undergoes significant transcriptomic remodeling during perinatal and early postnatal development.
  • The cellular basis and regulatory mechanisms of these developmental changes are not fully understood.

Purpose of the Study:

  • To systematically characterize the temporal dynamics of gene expression across major cell types in the developing human cerebral cortex.
  • To investigate the role of glial cells, particularly astrocyte subtypes, in neuronal maturation and circuit formation.

Main Methods:

  • Integration of single-cell and bulk RNA sequencing data across nine developmental stages of the human cerebral cortex.
  • Analysis of gene expression dynamics, cellular composition, and cell-cell communication.
  • Comparative analysis with mouse brain development.

Main Results:

  • Pronounced transcriptomic changes and shifts in cellular composition occur from late fetal stages to infancy.
  • Glial cells display gene expression patterns suggesting a role in neuronal maturation.
  • Distinct astrocyte subtypes show specific temporal interaction patterns with neurons, including human-specific features in synaptogenesis and axonogenesis.

Conclusions:

  • Astrocyte subtypes play a crucial role in supporting neuronal development and circuit formation in the postnatal human brain.
  • Developmental transitions of astrocyte subtypes correlate with transcriptomic divergence and neuronal maturation.
  • These findings provide insights into the origins of neurodevelopmental disorders.