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Related Experiment Videos

Diagnostic Prediction Models for Depression in Patients With Breast Cancer: A Systematic Review.

Xiaosong Yu1,2, Lin Zhang1, Qianqian Wan2,3

  • 1Department of Nursing, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.

Journal of Clinical Nursing
|May 20, 2026
PubMed
Summary

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Diagnostic prediction models for depression in breast cancer patients show promise but have methodological weaknesses. Current models are not robust enough for routine nursing practice due to quality concerns.

Area of Science:

  • Oncology
  • Psychiatry
  • Health Services Research

Background:

  • Depression is a significant concern for patients with breast cancer.
  • Accurate diagnostic prediction models are needed to identify at-risk individuals.

Purpose of the Study:

  • To systematically review existing evidence on diagnostic prediction models for depression in breast cancer patients.
  • To assess the quality and applicability of these models.

Main Methods:

  • Systematic review of studies developing or validating depression prediction models in breast cancer patients.
  • Searched ten databases up to December 2025.
  • Used CHARMS for data extraction and PROBAST for risk of bias and applicability assessment.

Main Results:

Keywords:
breast cancerdepressiondiagnostic prediction modelsystematic review

Related Experiment Videos

  • Eleven studies were included, with AUC values ranging from 0.784 to 0.890.
  • All studies had a high risk of bias, and seven had high concerns regarding applicability.
  • Common predictors included age, income, and family support, with substantial heterogeneity.

Conclusions:

  • Current diagnostic prediction models for depression in breast cancer patients are methodologically weak.
  • Limited external validation and calibration reporting hinder routine use in nursing.
  • Future research needs to standardize development, validation, and performance evaluation.