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Inflammatory bowel disease phenotypes in diverse populations: a global comparative analysis
Charles N Bernstein1, Gilaad G Kaplan2, Zoann Nugent1
1Department of Internal Medicine, University of Manitoba IBD Clinical and Research Centre, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, R3E3P4, Canada.
Journal of Crohn'S & Colitis
|May 20, 2026
Summary
Crohn
Area of Science:
- Gastroenterology and Epidemiology
Background:
- Investigating global variations in Crohn's disease (CD) and ulcerative colitis (UC) presentation.
- Understanding the worldwide epidemiology of Inflammatory Bowel Disease (IBD).
Purpose of the Study:
- To determine if Crohn's disease (CD) and ulcerative colitis (UC) exhibit similar clinical characteristics globally.
- Comparing IBD phenotypes across different geographical regions.
Main Methods:
- Global cohort data for CD and UC were collected and analyzed.
- Phenotype assessment utilized the Montreal Classification, stratifying by age, disease location, and behavior.
- Geographical data were categorized into
- Western
- and
- non-Western
- regions.
Main Results:
- Data from 54,868 IBD patients across Western and non-Western cohorts were analyzed.
- No significant differences in demographic or phenotypic distributions were observed for CD and UC between Western and non-Western countries.
- Western cohorts reported longer disease durations compared to non-Western cohorts.
Conclusions:
- Phenotypic data for Crohn's disease and ulcerative colitis showed no significant global variations.
- Findings suggest that Inflammatory Bowel Disease (IBD) manifests similarly worldwide.
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