Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 21, 2026

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

Beyond TG‑43: A PRISMA-based systematic review on model-based dose-calculation algorithms in brachytherapy.

Dat Tran1, Thanh-Tai Duong2, Shada Wadi-Ramahi3

  • 1Department of Physics, University of Houston, Houston, Texas, USA.

Journal of Applied Clinical Medical Physics
|May 20, 2026
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Artificial intelligence in radiation treatment planning: a narrative review from automation to clinical decision support.

Translational cancer research·2026
Same author

Deployment of a Tailored and Hybrid Educational Strategy for Wartime Capacity Building: American Association of Physicists in Medicine/Help Ukraine Group/Ukrainian Association of Medical Physicists Training Program to Transition Ukraine From Co-60 to Intensity-Modulated Radiation Therapy.

JCO global oncology·2026
Same author

Correction: Morozova et al. Insights into Sorption-Mineralization Mechanism for Sustainable Granular Composite of MgO-CaO-Al<sub>2</sub>O<sub>3</sub>-SiO<sub>2</sub>-CO<sub>2</sub> Based on Nanosized Adsorption Centers and Its Effect on Aqueous Cu(II) Removal. <i>Nanomaterials</i> 2022, <i>12</i>, 116.

Nanomaterials (Basel, Switzerland)·2026
Same author

From standard to stratified: Modeling NTCP and EAR to personalize daily MV-CBCT in radiotherapy.

Journal of applied clinical medical physics·2025
Same author

Hippocampal-Avoidance Whole-Brain Radiotherapy: Dosimetric Comparison of 3D-CRT, IMRT, and VMAT for Brain Metastases from Lung Cancer.

Cancers·2025
Same author

Applications of Nanomaterials in Biomedical Imaging and Cancer Therapy: 3rd Edition.

Nanomaterials (Basel, Switzerland)·2025
Same journal

Pulse‑level characterization of low monitor unit deliveries on a modern linear accelerator using a plastic scintillation detector.

Journal of applied clinical medical physics·2026
Same journal

Improving image quality in terbium-161 phantom imaging: Quantitative evaluation of DEW and TEW scatter correction methods.

Journal of applied clinical medical physics·2026
Same journal

Latent density discrepancies in commercial lung-equivalent inserts and their clinical dosimetric impact.

Journal of applied clinical medical physics·2026
Same journal

Explainable machine learning for patient-specific quality assurance in intensity-modulated radiotherapy based on anatomical structures.

Journal of applied clinical medical physics·2026
Same journal

Conditional sparing in FLASH radiotherapy: Conformal dosimetry and ALARA remain essential.

Journal of applied clinical medical physics·2026
Same journal

Dual-scan conformal cone-beam CT for targeted image-quality improvement using dynamic collimation.

Journal of applied clinical medical physics·2026
See all related articles
This summary is machine-generated.

The American Association of Physicists in Medicine Task Group 43 (TG-43) formalism is outdated for brachytherapy dose calculation. Model-based dose-calculation algorithms (MBDCAs) and Monte Carlo (MC) simulations offer superior accuracy and are ready for clinical adoption.

Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Computational Biology

Background:

  • The AAPM TG-43 formalism is the standard for brachytherapy dose calculation but assumes a homogeneous medium, neglecting tissue heterogeneities and scatter.
  • Model-based dose-calculation algorithms (MBDCAs), including Monte Carlo (MC) simulations, address these limitations by considering real tissue composition and scatter.

Purpose of the Study:

  • To systematically review and evaluate TG-43, MBDCAs, and MC methods for brachytherapy dose calculation.
  • Assess dosimetric accuracy, validation strategies, computational feasibility, and clinical implementation barriers.

Main Methods:

  • A PRISMA-guided literature search of the Scopus database identified 42 relevant studies.
  • Eligible studies compared TG-43, MBDCAs, and/or MCs in pelvic, breast, or head-and-neck brachytherapy.
Keywords:
AAPM TG‐43Acuros BVMonte Carlo simulationPRISMAadaptive radiotherapyartificial Intelligencebrachytherapyclinical implementationdose calculation accuracymodel‐based dose‐calculation algorithm

More Related Videos

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Radiation Planning Assistant - A Web-based Tool to Support High-quality Radiotherapy in Clinics with Limited Resources
05:18

Radiation Planning Assistant - A Web-based Tool to Support High-quality Radiotherapy in Clinics with Limited Resources

Published on: October 6, 2023

Related Experiment Videos

Last Updated: May 21, 2026

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Radiation Planning Assistant - A Web-based Tool to Support High-quality Radiotherapy in Clinics with Limited Resources
05:18

Radiation Planning Assistant - A Web-based Tool to Support High-quality Radiotherapy in Clinics with Limited Resources

Published on: October 6, 2023

  • Data extracted included dosimetric discrepancies, validation methods, computational performance, and workflow integration.

    • Main Results:

    • TG-43 showed variable bias depending on tissue composition and scatter; it often overestimated doses in homogeneous tissues but underestimated in low-density regions.
    • MBDCAs and MCs agreed within ~3% with experimental data, offering more reliable radiobiological metrics.
    • GPU acceleration and deep learning reduced computation times; standardization, commissioning, and QA remain challenges.

    Conclusions:

    • A transition to TG-186-compliant, heterogeneity-aware dose calculation frameworks is supported by evidence.
    • MBDCAs/MC algorithms offer superior accuracy and are compatible with adaptive and biologically guided planning.
    • Established QA standards and benchmarking datasets facilitate implementation, linking precision to patient outcomes.