Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aromatic Hydrocarbon Anions: Structural Overview01:18

Aromatic Hydrocarbon Anions: Structural Overview

Neutral hydrocarbons like cyclopentadiene with an odd number of carbon atoms and one intervening CH2 group in the ring are not aromatic. Cyclopentadiene with 4 π electrons does not satisfy the 4n + 2 π electron rule. Additionally, the intervening CH2 group is sp3 hybridized and lacks a vacant p orbital, thereby interrupting the overlap of p orbitals in a continuous manner and preventing the delocalization of π electrons throughout the ring.
Due to the absence of continuous overlap of p...
Aromatic Hydrocarbon Cations: Structural Overview01:18

Aromatic Hydrocarbon Cations: Structural Overview

Cycloheptatriene is a neutral monocyclic unsaturated hydrocarbon that consists of an odd number of carbon atoms and an intervening sp3 carbon in the ring. The three double bonds in the ring correspond to 6 π electrons, which is a Huckel number, and therefore satisfies the criteria of 4n + 2 π electrons. However, the intervening sp3 carbon disrupts the continuous overlap of p orbitals. As a result, cycloheptatriene is not aromatic.
Removing one hydrogen from the intervening CH2 group with both...
Aldehydes and Ketones with HCN: Cyanohydrin Formation Mechanism01:10

Aldehydes and Ketones with HCN: Cyanohydrin Formation Mechanism

Cyanohydrins are formed when cyanide nucleophiles and carbonyl compounds like aldehydes and ketones react. A strong base, the cyanide ion, catalyzes cyanohydrin formation. The ions are generated from HCN under aqueous conditions. Once the cyanide ions are generated, the first step involves the nucleophilic attack of the cyanide ions on the electrophilic carbonyl carbon. This attack shifts the π electrons from the C=O to the oxygen atom forming the alkoxide ion intermediate. The alkoxide anion...
Aldehydes and Ketones with HCN: Cyanohydrin Formation Overview01:32

Aldehydes and Ketones with HCN: Cyanohydrin Formation Overview

Cyanohydrins are compounds that contain –CN and –OH groups on the same carbon atom. They are formed by the nucleophilic addition of the cyanide ions to the carbonyl group. Cyanide ions are highly basic and nucleophilic and can be generated from HCN under aqueous conditions. However, since HCN is a weak acid, the number of cyanide ions generated is very small. Hence, a small amount of base or KCN/NaCN is added to HCN to increase the concentration of the cyanide ions in the reaction mixture.
Properties of Organometallic Compounds01:23

Properties of Organometallic Compounds

Organometallic compounds are compounds that contain a carbon–metal bond. Carbon belongs to an organyl group like alkyl, aryl, allyl, or benzyl groups. The metal can be from Group I or Group II of the periodic table, a transition metal, or a semimetal.
Introduction to Functional Groups02:08

Introduction to Functional Groups


Functional groups are group of atoms with specific chemical properties that occur within organic molecules and sometimes denoted as “R”. Functional groups are found along the carbon backbone of macromolecules can form chains or rings of carbon atoms. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of common functional groups
The table below summarizes some of the major functional groups in organic chemistry. (The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Seven Models for Outer Surface-Only Functionalized Nanofluidic Systems.

ACS nano·2026
Same author

Single crystal covalent organic frameworks.

Chemical Society reviews·2026
Same author

Electrolyte Covalent Organic Frameworks for Exceptional Potassium Ion Conduction.

Angewandte Chemie (International ed. in English)·2026
Same author

Geminal Atom Catalysts with Minimized d-Orbital Holes Enable β-Elimination-Resistant C(sp<sup>2</sup>)-C(sp<sup>3</sup>) Cross-Coupling.

Journal of the American Chemical Society·2026
Same author

One-Dimensional and Pseudo-Two-Dimensional Helicene Covalent Organic Frameworks.

Journal of the American Chemical Society·2026
Same author

De Novo Synthesis of Covalent Organic Frameworks: A Principle for Topology Selection and Profound π Electronic Effects.

Angewandte Chemie (International ed. in English)·2026
Same journal

Linker Engineering toward NIR-II Metal-Organic Framework with Maximal Emission beyond 1000 nm for Inflammatory Bowel Disease Imaging.

Journal of the American Chemical Society·2026
Same journal

Observing Kinetic Selectivity in Anthracene Photodimerization through Selective Quenching by Excited States of Proximate Rare Earth Cations.

Journal of the American Chemical Society·2026
Same journal

Sequence-Dependent Folding of Recognition-Encoded Melamine Oligomers.

Journal of the American Chemical Society·2026
Same journal

Large Thermo- and Mechanosalient Actuation via Cooperative Twist Elasticity-Induced Packing Motif Conversion.

Journal of the American Chemical Society·2026
Same journal

Discovery and Biosynthesis of Lanthipeptides Featuring an Azepinoindole Scaffold by Radical <i>S</i>-Adenosylmethionine Enzyme-Catalyzed C-C Bond Formation.

Journal of the American Chemical Society·2026
Same journal

Enantiopurity-Controlled Magnetism in a Two-Dimensional Organic-Inorganic Material.

Journal of the American Chemical Society·2026
See all related articles

Related Experiment Video

Updated: May 21, 2026

Microfluidic-based Synthesis of Covalent Organic Frameworks (COFs): A Tool for Continuous Production of COF Fibers and Direct Printing on a Surface
08:42

Microfluidic-based Synthesis of Covalent Organic Frameworks (COFs): A Tool for Continuous Production of COF Fibers and Direct Printing on a Surface

Published on: July 10, 2017

Acylhydrazone-Linked Covalent Organic Frameworks.

Haipei Shao1,2, Xingyao Ye1, Yongzhi Chen1

  • 1Department of Chemistry, Faculty of Science, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore.

Journal of the American Chemical Society
|May 20, 2026
PubMed
Summary
This summary is machine-generated.

This study introduces acylhydrazone-linked covalent organic frameworks (COFs) synthesized using ketones. These novel COFs exhibit enhanced stability, tunable light emission, and improved water adsorption properties.

More Related Videos

Synthesis of Single-Crystalline Core-Shell Metal-Organic Frameworks
05:26

Synthesis of Single-Crystalline Core-Shell Metal-Organic Frameworks

Published on: February 10, 2023

Synthesis and Characterization of Functionalized Metal-organic Frameworks
11:27

Synthesis and Characterization of Functionalized Metal-organic Frameworks

Published on: September 5, 2014

Related Experiment Videos

Last Updated: May 21, 2026

Microfluidic-based Synthesis of Covalent Organic Frameworks (COFs): A Tool for Continuous Production of COF Fibers and Direct Printing on a Surface
08:42

Microfluidic-based Synthesis of Covalent Organic Frameworks (COFs): A Tool for Continuous Production of COF Fibers and Direct Printing on a Surface

Published on: July 10, 2017

Synthesis of Single-Crystalline Core-Shell Metal-Organic Frameworks
05:26

Synthesis of Single-Crystalline Core-Shell Metal-Organic Frameworks

Published on: February 10, 2023

Synthesis and Characterization of Functionalized Metal-organic Frameworks
11:27

Synthesis and Characterization of Functionalized Metal-organic Frameworks

Published on: September 5, 2014

Area of Science:

  • Materials Science
  • Chemistry
  • Nanotechnology

Background:

  • Covalent organic frameworks (COFs) are crystalline porous materials with tunable structures.
  • Aldehydes are commonly used monomers for COF synthesis, but ketones remain underexplored.
  • Acylhydrazone linkages offer potential for novel COF architectures and properties.

Purpose of the Study:

  • To explore ketones as monomers for synthesizing COFs via acylhydrazone linkages.
  • To investigate the impact of reaction conditions on COF crystallinity and porosity.
  • To elucidate the role of acylhydrazone linkages in COF structure and function.

Main Methods:

  • Solvothermal synthesis of COFs using ketones and hydrazides.
  • Screening of reaction parameters (solvent, catalyst, temperature, time).
  • Characterization of COF structure, porosity, and properties.

Main Results:

  • Highly crystalline and porous acylhydrazone-linked COFs were successfully synthesized.
  • Acylhydrazone linkages enhanced pore confinement, water adsorption, and adsorption heat.
  • The COFs exhibited improved thermal/chemical stability, π-delocalization, tunable light emission, reduced bandgaps, and enhanced photoconductivity.

Conclusions:

  • Ketones can be effectively utilized as monomers for COF synthesis, expanding the scope of COF design.
  • Acylhydrazone linkages significantly influence COF structural and functional characteristics.
  • This work presents a new strategy for developing advanced COFs with tailored properties for diverse applications.