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Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish
Published on: May 15, 2021
The impact of low-volume hydration on kidney function in low-dose cisplatin therapy for biliary tract cancer: a
Hiroyuki Watanabe1, Katsuya Makihara2, Masahiko Nakao3
1Department of Pharmacy, Panasonic Health Insurance Organization Matsushita Memorial Hospital, Osaka, Japan.
Abstract:
Hydration is crucial for preventing cisplatin-induced nephrotoxicity; however, optimal hydration for low-dose cisplatin (<50 mg/m2) remains unclear. This multicentre retrospective study assessed whether low-volume hydration (LV, <1500 mL) is non-inferior to high-volume hydration (HV, ≥1500 mL) in patients with biliary tract cancer receiving gemcitabine plus cisplatin (25 mg/m2). Of 239 patients, 109 LV and 97 HV patients were analysed. Primary endpoint was acute kidney injury (AKI) incidence. Propensity score weighting was applied to adjust for confounders. Post-adjustment AKI incidence was 4.7% (LV) vs. 10.1% (HV), confirming non-inferiority (risk difference upper 95% CI: 0.002, margin <0.05). No significant differences were observed in serum creatinine or creatinine clearance trajectories. In conclusion, low-volume hydration was non-inferior to high-volume hydration for AKI risk in low-dose cisplatin therapy. These findings support tailoring hydration to reduce patient burden without compromising safety.
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