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Platelet indices and incident CKD in high-risk individuals

Kenichi Tanaka1,2,3, Hiroshi Kimura4,5, Hirotaka Saito4

  • 1Department of Nephrology and Hypertension, Fukushima Medical University, Fukushima, Japan. kennichi@fmu.ac.jp.

Clinical and Experimental Nephrology
|May 20, 2026
PubMed

Insights

Platelet indices like PDW and MPV may indicate risk for developing chronic kidney disease (CKD) in high-risk individuals. Further research is needed to confirm these associations.

Area of Science:

  • Nephrology
  • Hematology
  • Epidemiology

Background:

  • Platelet indices, such as platelet distribution width (PDW) and mean platelet volume (MPV), are indicators of platelet activation.
  • Previous studies suggest associations between platelet indices and kidney disease progression.
  • The link between PDW, MPV, and the incidence of chronic kidney disease (CKD) in high-risk populations remains uncertain.

Purpose of the Study:

  • To investigate the association between baseline platelet distribution width (PDW) and mean platelet volume (MPV) and the incidence of chronic kidney disease (CKD).
  • To evaluate these associations in a cohort of individuals with established risk factors for CKD.

Main Methods:

  • Retrospective analysis of longitudinal data from 1,281 participants in the Fukushima Cohort Study without pre-existing CKD.
  • Participants had at least one CKD risk factor: hypertension, diabetes mellitus, dyslipidemia, or history of cardiovascular disease.
  • Individuals were categorized into quartiles based on baseline PDW or MPV, with incident CKD as the primary outcome.

Main Results:

  • During a median follow-up of 5.2 years, 384 participants developed incident CKD.
  • Higher quartiles of PDW and MPV were associated with an increased cumulative incidence of CKD.
  • While PDW remained significantly associated with incident CKD in multivariable analysis, MPV did not, and continuous variable analyses showed no significant associations.

Conclusions:

  • PDW and MPV demonstrated potential associations with incident CKD in high-risk individuals.
  • The observed associations were not consistent across all analytical models.
  • These findings are considered hypothesis-generating and require further validation in independent cohorts.
Abstract

Keywords:
Chronic kidney diseaseEpidemiologyMean platelet volumeObservational studyPlatelet distribution width

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