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NFYB Integrates Hormonal Signals into Tissue Allometry by Promoting Protein Biosynthesis.

Fangfang Liu1, Shiming Zhu1, Sishi Xia1

  • 1Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, China.

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PubMed
Summary
This summary is machine-generated.

Juvenile hormone (JH) and 20-hydroxyecdysone (20E) control insect tissue growth. NFYB acts as a key gene, integrating these hormones to regulate fat body and wing pad allometry for proper body shape.

Keywords:
20‐hydroxyecdysonefat bodyjuvenile hormoneprotein biosynthesiswing pads

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Area of Science:

  • Developmental biology
  • Endocrinology
  • Insect physiology

Background:

  • Tissue allometry, crucial for body size and shape, is hormonally regulated.
  • Juvenile hormone (JH) and 20-hydroxyecdysone (20E) are key insect growth regulators, but their roles in tissue allometry are not fully understood.

Purpose of the Study:

  • To elucidate the distinct roles of JH and 20E in regulating tissue-specific allometry during insect development.
  • To identify the molecular mechanisms and key genes involved in mediating hormonal control of tissue allometry.

Main Methods:

  • Comparative transcriptomic analysis of fat body and wing pads across nymphal instars.
  • Hormone treatment experiments (JH and 20E) on specific tissues.
  • Identification and functional analysis of key regulatory genes.

Main Results:

  • JH promotes early, significant fat body expansion, while 20E drives late, rapid wing pad growth.
  • NFYB was identified as a central spatiotemporal factor gene regulating these distinct tissue allometric processes.
  • NFYB transcriptionally activates protein biosynthesis machinery in a tissue- and stage-specific manner.

Conclusions:

  • NFYB acts as a spatiotemporal integrator of hormonal signals (JH and 20E) to orchestrate distinct tissue allometry.
  • This mechanism is critical for achieving appropriate body shape and size during insect development.
  • The findings provide insights into the molecular basis of how hormonal cues translate into differential tissue growth patterns.