Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vaccinations01:51

Vaccinations

Overview
Vaccines01:21

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...
Ethical Dilemmas I01:17

Ethical Dilemmas I

Ethical dilemmas in nursing are of utmost importance, as they often arise from the tension between adhering to core ethical principles and the practical realities of healthcare delivery. These dilemmas require nurses to navigate complex situations where competing ethical considerations pull them in different directions.
Let us explore some examples to understand the potentially complex moral decisions nurses face.
Take the case of caring for minors, particularly in areas related to reproductive...
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Preparedness and Phobias01:09

Preparedness and Phobias

Human fear responses to certain stimuli, such as darkness, heights, deep water, and blood, can often arise despite the absence of direct negative experiences. This phenomenon is rooted in evolutionary psychology, which posits that humans have developed a predisposition to fear stimuli that historically posed significant survival threats. This predisposition, known as preparedness, suggests that early humans who developed a fear of potentially dangerous entities, such as venomous snakes and...
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Australian adults' views on influenza vaccination: Implications for communication and service quality from a qualitative study.

Vaccine·2026
Same author

Funding for School Based Health Care Mental Health Services is Essential for Latino Youth.

Journal of health care for the poor and underserved·2026
Same author

Effectiveness of an online vaccine misinformation game for Arabic-speaking Australians: a randomized controlled trial.

Frontiers in public health·2026
Same author

Rotavirus Vaccines Are Safe and Effective: So Why Aren't All Children Protected?

Pediatrics·2026
Same author

Influence of Community-Level Factors on Health Care Provider Recommendations for HPV Vaccine.

Pediatrics open science·2026
Same author

The Maternal Vaccine Study Protocol: A Victorian Cohort Study Evaluating Infant and Childhood Safety and Health and Developmental Outcomes After Vaccination Against Respiratory Viruses in Pregnancy.

Vaccines·2026
Same journal

Ebola at 50 - Lessons for Outbreak Response and Preparedness.

The New England journal of medicine·2026
Same journal

Ianalumab plus Eltrombopag in Immune Thrombocytopenia. Reply.

The New England journal of medicine·2026
Same journal

Ianalumab plus Eltrombopag in Immune Thrombocytopenia.

The New England journal of medicine·2026
Same journal

Hypertension Control in Low-Income Patients. Reply.

The New England journal of medicine·2026
Same journal

Hypertension Control in Low-Income Patients.

The New England journal of medicine·2026
Same journal

Hypertension Control in Low-Income Patients.

The New England journal of medicine·2026
See all related articles

Related Experiment Video

Updated: May 22, 2026

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
08:52

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

Childhood Vaccine Hesitancy.

Sean T O'Leary1,2, Margie Danchin3,4,5

  • 1Adult and Child Center for Outcomes Research and Delivery Science, University of Colorado School of Medicine, Children's Hospital Colorado, Aurora.

The New England Journal of Medicine
|May 20, 2026
PubMed
Summary
This summary is machine-generated.

Most parents hesitant about childhood vaccines are motivated by child safety concerns. Clear clinician communication and empathy-driven strategies improve vaccine uptake and trust.

More Related Videos

Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens
13:47

Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens

Published on: May 19, 2020

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen
07:44

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen

Published on: May 12, 2023

Related Experiment Videos

Last Updated: May 22, 2026

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
08:52

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens
13:47

Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens

Published on: May 19, 2020

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen
07:44

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen

Published on: May 12, 2023

Area of Science:

  • Pediatrics
  • Public Health
  • Vaccinology

Background:

  • Vaccine hesitancy presents a significant challenge to public health.
  • Parents' concerns often stem from safety worries, despite established vaccine safety records.
  • Routine childhood immunizations have drastically reduced disease incidence.

Purpose of the Study:

  • To explore effective communication strategies for addressing parental vaccine hesitancy.
  • To identify methods for increasing childhood vaccine uptake.
  • To understand the role of clinician recommendations in parental decision-making.

Main Methods:

  • Review of existing literature on vaccine communication and hesitancy.
  • Analysis of parental motivations and concerns regarding childhood vaccines.
  • Evaluation of communication approaches, including presumptive and empathy-driven strategies.

Main Results:

  • Clinicians are the most trusted source for vaccine information.
  • Confident, clear recommendations from healthcare providers significantly increase vaccine uptake.
  • Presumptive communication and respectful dialogue are more effective than open-ended discussions.
  • Empathy-driven strategies like motivational interviewing help build trust and address misinformation.

Conclusions:

  • Effective communication is crucial for overcoming vaccine hesitancy.
  • Patient-centered, empathy-driven approaches foster trust and encourage future vaccination.
  • Strengthening the clinician-parent relationship supports informed vaccination decisions.