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Related Experiment Video

Updated: May 22, 2026

Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves
11:12

Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves

Published on: October 17, 2013

Toward digital twin-enabled venous flow modelling: Interactive valve geometry and lab-on-chip generation framework.

Vineeth Vijaya Kumar1, Chris Harris2, Vinod Kumar1

  • 1Mechanical & Industrial Engineering, Texas A&M University, Kingsville, TX, USA.

Computers in Biology and Medicine
|May 20, 2026
PubMed
Summary
This summary is machine-generated.

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A new web framework generates realistic venous valve geometries for studying deep vein thrombosis (DVT). This tool aids research by enabling parametric exploration and rapid prototyping of valve models for simulations.

Area of Science:

  • Biomedical Engineering
  • Computational Biology
  • Medical Imaging

Background:

  • Deep vein thrombosis (DVT) often originates in venous valve sinus regions.
  • Accurate geometric modeling of venous valves is crucial for understanding DVT.
  • Existing methods may lack the flexibility for detailed parametric analysis.

Purpose of the Study:

  • To introduce a web-based framework for real-time generation and meshing of venous valve geometry.
  • To provide a physiologically inspired, parametric model for DVT research.
  • To facilitate rapid prototyping and simulation of venous valve morphologies.

Main Methods:

  • Development of a web-based interface for manipulating venous valve parameters (e.g., vein radius, sinus dimensions, leaflet properties).
Keywords:
Deep vein thrombosis (DVT)Digital twinVenous valveWeb-based interface

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Last Updated: May 22, 2026

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Published on: October 17, 2013

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  • Generation of 2D and 3D geometric models, exportable as STL files.
  • Creation of high-quality hexagonal lattice meshes with Delaunay triangulation for CFD simulations.

    • Main Results:

    • Demonstration of interactive parametric exploration influencing flow dynamics and recirculation zones.
    • Identification of regions prone to thrombus formation under low shear conditions.
    • Successful generation of meshes suitable for computational fluid dynamics (CFD) analysis.

    Conclusions:

    • The framework enables interactive parametric exploration and rapid prototyping for thrombogenesis studies.
    • It serves as a scalable tool bridging computational design, simulation, and experimental validation.
    • The pipeline supports integration with Digital Twin platforms for patient-specific venous flow modeling.