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Updated: May 22, 2026
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Investigating the Immunological Mechanisms Underlying Organ Transplant Rejection
Published on: August 20, 2007
Invasive mold infections among transplant recipients: A single-center observational study
Sukanya Sudhaharan1, Umabala Pamidimukkala1, Shivani Bojja1
1Department of Microbiology, ICMR-Advanced Mycology Diagnostic and Research Centre, Nizam's Institute of Medical Sciences, Panjagutta, Hyderabad-500082, Telangana, India.
Journal De Mycologie Medicale
|May 20, 2026
Summary
Invasive mold infections (IMI) are a significant risk for transplant recipients in India. Mucormycosis and aspergillosis were the most common IMI, often affecting the lungs within six months post-transplant.
Area of Science:
- Medical Mycology
- Transplant Infectious Diseases
- Clinical Microbiology
Background:
- Transplant recipients face high mortality from invasive fungal infections (IFI).
- Epidemiology of IFI varies by transplant type, with limited Indian data on invasive mold infections (IMI).
Purpose of the Study:
- To determine the clinical and microbiological spectrum of mold infections in solid organ and hematopoietic stem cell transplant recipients in India.
Main Methods:
- Retrospective analysis of SOT and HSCT patients with IMI from January 2023 to December 2025.
- Inclusion based on EORTC/MSG criteria; data extracted and analyzed.
Main Results:
- 3.6% overall IMI incidence; highest in lung (33.3%) and renal (3.8%) transplants.
- Mucormycosis (43.7%) and aspergillosis (31.25%) were predominant; lungs most affected.
- Most infections occurred within six months post-transplant; males predominated (median age 37).
Conclusions:
- Mucorales species are the primary cause of IMI in Indian transplant recipients.
- Early recognition of IMI, including rare molds, is critical for timely treatment and improved survival.
