Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...

Local Anesthetics: Clinical Application as Epidural Anesthesia

Local Anesthetics: Clinical Application as Epidural Anesthesia

Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...

Imaging Studies III: Computed Tomography

Imaging Studies III: Computed Tomography

DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...

Drug Accumulation During Multiple Dosing: Repetitive IV Injections

Drug Accumulation During Multiple Dosing: Repetitive IV Injections

Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...

Imaging Studies VII: Vascular Imaging

Imaging Studies VII: Vascular Imaging

DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...

Non-Oral Extravascular Drug Absorption Routes

Non-Oral Extravascular Drug Absorption Routes

Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more effectively...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Dynamic Spinal Stenosis in Intradiscal Vacuum Phenomenon: Insights from Standing Weight Bearing CT Myelography.

AJNR. American journal of neuroradiology·2026

Same author

Elevated CSF Beta Trace Protein Levels in Patients with CSF-Venous Fistulas.

AJNR. American journal of neuroradiology·2026

Same author

A potential Adjunctive Role of 7T MRI and Amino-Acid PET in Localizing MRI-Occult Functional Pituitary Microadenomas: A Scoping Review.

AJNR. American journal of neuroradiology·2026

Same author

The 2026 AHA/ASA Guideline Updates to Management of Patients with Acute Ischemic Stroke: A Guide for Radiologists.

AJNR. American journal of neuroradiology·2026

Same author

The Future of AI and Radiology Is Not as Simple as You Think.

Radiology·2026

Same author

Preventing wrong-site vertebroplasty procedures: An iterative quality improvement project.

AJNR. American journal of neuroradiology·2026

Search research articles

Related Experiment Video

Updated: May 22, 2026

Contrast Enhanced Ultrasound Imaging for Assessment of Spinal Cord Blood Flow in Experimental Spinal Cord Injury

Contrast Enhanced Ultrasound Imaging for Assessment of Spinal Cord Blood Flow in Experimental Spinal Cord Injury

Published on: May 7, 2015

Rapid Systemic Absorption of Epidural Iodinated Contrast: Observations from Multilevel Blood Patching.

John P Welby¹, Ian T Mark², Carrie M Carr²

¹From the Division of Neuroradiology (J.P.W., I.T.M., C.M.C., J.C.B., J.T.V., B.J.-T.), Department of Radiology, Mayo Clinic, Rochester, Minnesota. Welby.John@mayo.edu.

AJNR. American Journal of Neuroradiology

|May 20, 2026

Summary

Systemic absorption of iodinated contrast from the epidural space occurs rapidly, within 30 minutes. This finding is crucial for understanding the systemic effects of epidural injections and avoiding misinterpretation as pathology.

More Related Videos

An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach

An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach

Published on: December 7, 2016

Related Experiment Videos

Last Updated: May 22, 2026

Contrast Enhanced Ultrasound Imaging for Assessment of Spinal Cord Blood Flow in Experimental Spinal Cord Injury

Contrast Enhanced Ultrasound Imaging for Assessment of Spinal Cord Blood Flow in Experimental Spinal Cord Injury

Published on: May 7, 2015

An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach

An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach

Published on: December 7, 2016

Area of Science:

Radiology
Neurosurgery
Pharmacology

Background:

Systemic absorption from the spinal epidural space is a known but underexplored process, particularly concerning iodinated contrast agents.
Understanding this absorption is vital for interpreting imaging findings and potential systemic effects of epidural injections.

Purpose of the Study:

To evaluate the systemic absorption of iodinated contrast from the epidural space using CT imaging of the renal collecting system.
To assess the timeframe of contrast absorption following epidural injection during CT-guided epidural blood patching.

Main Methods:

Seventeen patients undergoing CT-guided multilevel nontargeted dorsal interlaminar epidural blood patching were included.
Dorsal epidural contrast injections (Omnipaque 300) were administered at 2-4 levels, followed by blood patching.
Renal collecting system imaging was performed pre- and post-contrast/blood patching to assess contrast presence.

Main Results:

Contrast was visualized in the renal collecting systems of 100% of patients.
Renal contrast appeared on average 23 minutes after the initial epidural contrast injection.
No contrast was visible on initial pre-procedure imaging.

Conclusions:

Systemic absorption of contrast from epidural injections is consistently observed within 30 minutes.
This provides imaging evidence of rapid epidural space uptake, informing understanding of systemic effects.
Findings suggest contrast absorption should not be misdiagnosed as pathology or an indicator of CSF leaks.