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Updated: May 22, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
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[Recent advances in the management of iron deficiency and iron deficiency anemia during pregnancy]

J Zhang1, M Chen2

  • 1Department of Hematology, Peking Union Medical College Hospital and Chinese Academy of Medical Sciences, Beijing 100730, China Department of Hematology, Beijing Sixth Hospital, Beijing 100007, China.

Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi
|May 20, 2026
PubMed

Iron deficiency (ID) and iron deficiency anemia (IDA) are common obstetric complications associated with various adverse pregnancy outcomes. According to the latest evidence-based medical evidence, this article reviews the management strategies for ID and IDA during pregnancy. Intravenous iron therapy provides substantial advantages for patients who cannot tolerate or do not respond to oral iron, as well as for those with severe IDA requiring rapid correction. The application of new-generation intravenous iron agents has improved treatment efficiency; however, their safety in the first trimester warrants further evaluation. Further, monitoring for adverse events, including hypophosphatemia, is necessary. This review further examines the differential diagnosis and management of intravenous iron-related hypersensitivity reactions and complement activation-related pseudoallergy. Management should be individualized based on patient-specific factors in clinical practice, with adherence to evidence-based guidelines to optimize maternal and infant outcomes.

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