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Updated: May 22, 2026

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
Published on: June 12, 2021
Hijacked on arrival: glucocorticoids enable disseminated tumor cell immune evasion
Yu Lou1, Adam C May2, Mikala Egeblad1
1Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Abstract:
Upon leaving the protective microenvironment of the primary tumor, disseminating tumor cells (DTCs) must withstand immune surveillance on their own. Cassandras et al. recently demonstrated that activation of the glucocorticoid receptor pathway serves as a critical mechanism for immune evasion during metastatic outgrowth from DTCs.
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