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Updated: May 22, 2026

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
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Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Published on: May 26, 2021

Clonal haematopoiesis and cardiovascular disease, defining risk, filling gaps, and framing the future

Alec P Morley1,2, Paul Carter3, Rupen Hargreaves4

  • 1Gonville and Caius College, University of Cambridge, Cambridge, UK.

NPJ Cardiovascular Health
|May 20, 2026
PubMed

Clonal haematopoiesis (CH) refers to the clonal expansion of haematopoietic stem cells in the absence of overt haematological malignancy and is common in older individuals. Recent evidence has heralded CH as a novel determinant of cardiovascular disease. This review explores the associations of CH with ischaemic heart disease, heart failure, atrial fibrillation and cardio-oncology, highlighting biases in the literature, exploring effects of mutation and clone size, concluding with clinical implications.

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