Polynucleotide (PN) Therapy for Accelerated Wound Repair and Scar Modulation in Aesthetic Procedures

Area of Science:

• Aesthetic medicine
• Regenerative medicine
• Dermatology

Background:

• Postoperative wound complications like delayed healing and scarring are common after aesthetic procedures.
• Patients with compromised microcirculation or comorbidities face higher risks of wound issues.

Purpose of the Study:

• To evaluate the clinical utility of injectable polynucleotide as a supplementary treatment for wound healing and scar management post-aesthetic procedures.

Main Methods:

• Retrospective case series of eight patients with significant wound healing delays or scarring.
• Treatment involved individualized injectable polynucleotide (Rejuran) sessions over 2-3 week intervals.
• Outcomes assessed via clinical photography and physician ratings of wound and scar characteristics.

Main Results:

• All patients experienced clinical improvements, including enhanced re-epithelialization, reduced erythema, and scar flattening.
• Improved contour and complete wound closure were observed in treated patients.
• No adverse events were reported, indicating a favorable safety profile.

Conclusions:

• Injectable polynucleotide therapy is a safe and effective adjunct for postoperative wound care and scar modulation in aesthetic practice.
• Early application, particularly during the inflammatory phase, may enhance outcomes.
• Further prospective studies with standardized measures are recommended to validate findings.