Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Specialized Care Centers and Settings-II01:30

Specialized Care Centers and Settings-II

Rural Health Centers
Rural health centers are specialized care facilities in remote locations with very few medical personnel. The primary care providers who run the centers are mostly Registered Nurse Practitioners. Here, emergency treatment is provided to critically ill or injured patients before they are transferred to the closest hospital. Fortunately, due to advancement in technology, many rural healthcare facilities and professionals have easy access to diagnostic and treatment...
Clinically Relevant Drug Product Specifications: Methods of Establishment01:29

Clinically Relevant Drug Product Specifications: Methods of Establishment

Product specifications define the acceptable quality of a pharmaceutical product by ensuring identity, purity, potency, and strength. These specifications serve as benchmarks during development, manufacturing, and post-approval quality control. Clinically relevant specifications are particularly important because they directly relate to a drug's safety and efficacy in clinical use.Dissolution studies are critical biopharmaceutic tools that link in vitro behavior to in vivo performance. They...
Preclinical Development: Overview01:28

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
Urologic Endoscopic Procedure: Cystoscopic Examination01:28

Urologic Endoscopic Procedure: Cystoscopic Examination

Meaning of Cystoscopic Examination:Cystoscopy is an essential diagnostic tool in urology that is used to assess the structure and function of the genitourinary system. It provides a direct view of the urethra, bladder, and, in some cases, the ureteral openings. This procedure helps detect structural abnormalities, infections, cancers, and blockages in the urinary tract. There are two types of cystoscopy:Flexible cystoscopy is commonly performed in outpatient settings due to its less invasive...
Specialized Care Centers and Settings-I01:30

Specialized Care Centers and Settings-I

Specialized care settings or centers are situated in convenient locations within the community and offer care to a specific group or population. They consist of daycare facilities, mental health facilities, rural health facilities, educational institutions, industries, shelters for the homeless, and rehabilitation facilities.
Daycare centers
They provide several functions. Some facilities care for healthy newborns and children whose parents work, while others are medically focused and care for...
Effects of EDTA on End-Point Detection Methods01:18

Effects of EDTA on End-Point Detection Methods

Different methods, such as visual observance of metal-ion indicators, spectroscopic techniques, and potentiometric methods, can determine the endpoint of an EDTA titration.
In the visual method, metal-ion indicators (metallochromic dyes), which have distinct colors in their free and complex forms, are added to the mixture to signal the titration's end point. They form stable complexes with metal ions, but these complexes are weaker than the corresponding metal–EDTA complexes. As a result, EDTA...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>MERTK</i>-associated retinal dystrophy: clinical course and imaging.

Ophthalmic genetics·2026
Same author

De novo and inherited dominant variants in U4 and U6 snRNA genes cause retinitis pigmentosa.

Nature genetics·2026
Same author

A practical introduction to wavelet analysis in electroretinography.

Documenta ophthalmologica. Advances in ophthalmology·2025
Same author

Vitreoretinal complications and surgical outcomes in patients with X-linked retinoschisis.

Acta ophthalmologica·2025
Same author

Incomplete congenital stationary night blindness associated with a novel variant in the CACNA1F gene.

Documenta ophthalmologica. Advances in ophthalmology·2025
Same author

OCT Biomarkers in a Cohort of Patients With <i>PRPF31</i>-Associated Retinitis Pigmentosa.

Journal of ophthalmology·2025
Same journal

Bilateral perifoveal macular ischemia in non-proliferative Duchenne muscular dystrophy-associated retinopathy: a case report.

Documenta ophthalmologica. Advances in ophthalmology·2026
Same journal

Association between dynamic pupil parameters and corneal sub-basal nerve plexus morphology.

Documenta ophthalmologica. Advances in ophthalmology·2026
Same journal

Structure-function relationship between handheld photopic negative response and macular GCIPL thickness in chronic optic neuropathy.

Documenta ophthalmologica. Advances in ophthalmology·2026
Same journal

Clinical course of a patient with PRSS56-associated nanophthalmos (isolated microphthalmia) and uveal effusion syndrome.

Documenta ophthalmologica. Advances in ophthalmology·2026
Same journal

Congenital grouped albinotic spots of the retinal pigment epithelium-a case report.

Documenta ophthalmologica. Advances in ophthalmology·2026
Same journal

Screening for RPE65 genetic variants in Egyptian children with inherited retinal disorders: a study from a tertiary eye care center in Egypt.

Documenta ophthalmologica. Advances in ophthalmology·2026
See all related articles

Related Experiment Video

Updated: May 22, 2026

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies
10:38

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies

Published on: January 16, 2019

Clinical endpoints special session, ISCEV 2025, Utrecht.

R Hamilton1,2, D Birch3, K Stingl4

  • 1Department of Clinical Physics & Bioengineering, Royal Hospital for Children, Glasgow, UK.

Documenta Ophthalmologica. Advances in Ophthalmology
|May 20, 2026
PubMed
Summary
This summary is machine-generated.

Clinical endpoint evaluation for inherited retinal disorders (IRDs) needs improvement. Discussions emphasized anchoring new endpoints to meaningful outcomes and reducing patient assessment burdens for better trial efficiency.

Keywords:
Clinical endpointsClinical trialsPatients perspectiveRetinal dystrophies

More Related Videos

A Cross-Disciplinary and Multi-Modal Experimental Design for Studying Near-Real-Time Authentic Examination Experiences
08:33

A Cross-Disciplinary and Multi-Modal Experimental Design for Studying Near-Real-Time Authentic Examination Experiences

Published on: September 4, 2019

Paper-based Devices for Isolation and Characterization of Extracellular Vesicles
11:53

Paper-based Devices for Isolation and Characterization of Extracellular Vesicles

Published on: April 3, 2015

Related Experiment Videos

Last Updated: May 22, 2026

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies
10:38

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies

Published on: January 16, 2019

A Cross-Disciplinary and Multi-Modal Experimental Design for Studying Near-Real-Time Authentic Examination Experiences
08:33

A Cross-Disciplinary and Multi-Modal Experimental Design for Studying Near-Real-Time Authentic Examination Experiences

Published on: September 4, 2019

Paper-based Devices for Isolation and Characterization of Extracellular Vesicles
11:53

Paper-based Devices for Isolation and Characterization of Extracellular Vesicles

Published on: April 3, 2015

Area of Science:

  • Ophthalmology
  • Clinical Trials
  • Genetics

Background:

  • Inherited retinal disorders (IRDs) present challenges in clinical trial endpoint selection.
  • The International Society for Clinical Electrophysiology of Vision (ISCEV) convened a special session to address these challenges.

Purpose of the Study:

  • To summarize discussions on the current state and future directions of clinical endpoints in IRD trials.
  • To identify key challenges and propose solutions for endpoint development and implementation.

Main Methods:

  • A summary of a special session at the 62nd ISCEV annual symposium.
  • Involved clinicians, regulators, industry, and patients in discussions.

Main Results:

  • Current endpoints may not be fully adequate for the heterogeneity of IRDs.
  • Disease heterogeneity, regulatory expectations, and operational feasibility pose significant challenges.
  • Patient perspectives are crucial for endpoint development.

Conclusions:

  • Emerging endpoints must be validated against clinically meaningful outcomes.
  • Minimizing the assessment burden on patients is essential for trial success.
  • Collaboration among stakeholders is vital for advancing IRD clinical trials.