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Related Experiment Video

Updated: May 22, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

Insights into the Micronutrient and Cardiovascular Health Risks during Pregnancy.

Xiangdong Wang¹, Lei Zhang¹, Xuehai Wang¹

¹Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China; MOE Key Laboratory of Population Health Across Life Cycle, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Provincial Key Laboratory of Environment and Population Health Across the Life Course, Anhui Medical University, Hefei, China.

The Journal of Nutrition

|May 20, 2026

Summary

Maintaining balanced serum iron and copper levels during pregnancy is crucial for cardiovascular health. Both deficiency and excess of these essential metals can impact pregnancy cardiovascular risks and biomarkers.

Keywords:

E-selectin ICAM-1 cardiovascular health micronutrients pregnancy

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Last Updated: May 22, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes

Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes

Published on: June 28, 2024

Area of Science:

Obstetrics and Gynecology
Cardiovascular Health
Nutritional Science

Background:

Maternal serum calcium (Ca), iron (Fe), and copper (Cu) levels during pregnancy have complex effects on cardiovascular health.
The precise dose-response relationship between these essential metals and cardiovascular risk (CVR) remains unclear.

Purpose of the Study:

To investigate the impact of serum copper (Cu), iron (Fe), and calcium (Ca) on cardiovascular health risks (CVR) in pregnant women.
To examine the association between these essential metals and biomarkers of endothelial cell activation (CAMs), specifically ICAM-1 and E-selectin.

Main Methods:

Analysis of 2,430 pregnant women from the Hefei II Maternal and Infant Health cohort study.
Cardiovascular risk (CVR) was assessed using five clinical indicators between 24-28 gestational weeks.
Serum levels of Cu, Fe, Ca, and CAMs (ICAM-1, E-selectin) were measured in maternal blood, with follow-up assessments in a subset.

Main Results:

Over half (54.3%) of pregnant women exhibited increased CVR.
Moderate iron (Fe) status (Q2, Q3) was linked to lower CVR odds compared to deficiency (Q1), while high Fe showed a U-shaped association with ICAM-1.
Higher copper (Cu) levels were associated with increased CVR odds, whereas no significant associations were found for CAMs in late pregnancy or cord blood.

Conclusions:

Maintaining optimal serum micronutrient levels, avoiding both deficiency and excess, is key for maternal cardiovascular health during pregnancy.
This study offers novel insights into the intricate relationship between essential serum micronutrients and cardiovascular health risks in pregnant populations.