Related Experiment Video
Updated: May 22, 2026
06:48
Breakfast Habits among Schoolchildren in the City of Uruguaiana, Brazil
Published on: July 29, 2020
Dietary Patterns and Asthma Endotypes in Puerto Rican Youth.
Allen Joe1, Franziska J Rosser1, Kristina Gaietto1
1Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA.
Chest
|May 20, 2026
Summary
An unhealthy diet is linked to T helper 17 high asthma in Puerto Rican youth. This suggests T helper 17 pathways may mediate diet’s effects on asthma development.
Area of Science:
- Pediatric Allergy and Immunology
- Nutritional Epidemiology
- Molecular Asthma Pathogenesis
Background:
- Diet significantly influences asthma pathogenesis, which is a complex syndrome with distinct endotypes.
- Limited research exists on the relationship between diet and specific asthma endotypes in pediatric populations.
Purpose of the Study:
- To investigate the association between dietary patterns and T helper 17 (T17)-high asthma in Puerto Rican children and adolescents.
- To explore if T17 pathways mediate the impact of diet on asthma.
Main Methods:
- Cross-sectional and longitudinal analyses were conducted on 465 and 358 Puerto Rican youths, respectively.
- A dietary score was developed from food frequency questionnaires, with an unhealthy diet defined as a nonpositive score.
- Asthma endotypes (T2-high, T17-high, T2-low/T17-low) were identified based on nasal epithelial gene expression.
Main Results:
- Cross-sectional analysis showed an unhealthy diet was associated with increased odds of T17-high asthma (OR=2.31).
- Prospective analysis revealed that an unhealthy diet at both study visits increased the odds of T17-high asthma (OR=4.30) and T2-low/T17-low asthma (OR=2.48).
Conclusions:
- An unhealthy diet is significantly associated with T17-high asthma in Puerto Rican youth.
- Findings suggest that T17 immune pathways may play a role in mediating the effects of diet on asthma.
More Related Videos
06:34A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
Published on: June 4, 2017
05:31Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
Related Concept Videos
01:26Asthma-II: Pathophysiology and Classification
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
01:13Asthma III: Clinical Manifestations
Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
01:20Asthma: Pathogenesis and Management
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
01:29Asthma-I: Introduction
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
01:28Asthma I: Introduction
Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
01:19Antiasthma Drugs: Leukotriene Modifiers
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms: