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Identifying Promising Practices in Lifestyle Intervention Programs for the Prediabetes Population: A Meta-Analysis
Jincheng Rong1, Mandy Ho1, Disheng Zhou1
1School of Nursing, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.
Worldviews on Evidence-Based Nursing
|May 21, 2026
Summary
Lifestyle interventions effectively prevent type 2 diabetes. Achieving significant weight loss and incorporating supervised exercise are key strategies for successful diabetes prevention programs.
Area of Science:
- Metabolic health and diabetes prevention research.
- Evidence-based practice in public health.
- Clinical trial meta-analysis and systematic review.
Background:
- Lifestyle interventions are proven effective for type 2 diabetes prevention.
- A gap exists in translating evidence-based lifestyle interventions into real-world settings.
- Prediabetes management is crucial for preventing type 2 diabetes progression.
Purpose of the Study:
- To summarize evidence on participant characteristics and intervention components influencing lifestyle interventions for prediabetes.
- To identify factors associated with the effectiveness of diabetes prevention programs.
- To inform the implementation of successful prediabetes interventions.
Main Methods:
- Systematic review and meta-analysis of randomized controlled trials (RCTs).
- Searched PubMed, Embase, Cochrane Library, and Web of Science databases.
- Included RCTs of lifestyle interventions (diet/physical activity) in adults with prediabetes.
Main Results:
- Seventy-seven studies (22,629 participants) were analyzed.
- Greater weight loss correlated with reduced diabetes incidence and increased normoglycemia rates.
- Supervised exercise training and interventions targeting younger individuals with lower HbA1c showed enhanced effectiveness.
Conclusions:
- Weight loss is a critical determinant in diabetes prevention; goal setting and monitoring are recommended.
- Supervised exercise sessions enhance the effectiveness of lifestyle interventions for prediabetes.
- Early intervention in younger individuals with lower HbA1c levels may be more effective for diabetes prevention.
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