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Related Experiment Video

Updated: May 22, 2026

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

Electrically Modulated Semi-Convertible Hydrogel Microneedles for Programmable Insulin Delivery.

Hongyue Jiang¹, Xinze Zhang¹, Xiang Li¹

¹State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, P. R. China.

Advanced Materials (Deerfield Beach, Fla.)

|May 21, 2026

Summary

A new wearable microneedle system uses electrical stimulation to precisely control insulin delivery for type 1 diabetes management. This innovative hydrogel technology mimics natural pancreatic function for improved blood glucose regulation.

Keywords:

gel‐sol transition insulin delivery programmable semi‐convertible hydrogel wearable device

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Last Updated: May 22, 2026

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Fabrication of a Master Mold for Microneedles with a Micron-sized Air-vent Hole

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Published on: December 5, 2025

Area of Science:

Biomaterials Science
Drug Delivery Systems
Endocrinology

Background:

Current insulin delivery methods for type 1 diabetes often lack sustained and precise control.
Mimicking the pancreas's dynamic insulin secretion is a key goal for improved diabetes management.

Purpose of the Study:

To develop a wearable, electrically modulated microneedle system for self-regulated insulin delivery.
To create a system capable of sustained and precise insulin release for type 1 diabetes treatment.

Main Methods:

A semi-convertible hydrogel microneedle system combining silk fibroin and polyethylene glycol/chitosan was engineered.
Flexible electrodes induced a gel-sol phase transition in the hydrogel under 1.2 V electrical stimulation for insulin release.
The system's performance was evaluated in type 1 diabetic mouse models.

Main Results:

Electrical stimulation triggered insulin release via silk fibroin phase transition and polymer network expansion.
Insulin release was controlled by electrical signals, with passive diffusion occurring when stimulation ceased.
A single microneedle patch demonstrated segmented control, with effects lasting up to 16 hours.

Conclusions:

The developed microneedle system offers a versatile and precise approach to insulin delivery.
This technology shows significant potential for long-term, self-regulated management of type 1 diabetes.
The electrically modulated system provides a promising strategy for chronic disease management.