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Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation
Published on: November 10, 2023
Burkholderia vietnamiensis Bacteraemia After Lung Transplantation in a Patient With Diffuse Panbronchiolitis
Taiki Ryo1, Ken-Ichi Iwata2,3, Toyofumi Fengshi Chen-Yoshikawa1
1Department of Thoracic Surgery Nagoya University Graduate School of Medicine Nagoya Japan.
Abstract:
Lung transplant recipients are at risk of opportunistic infections because of immunosuppression. We report a case of Burkholderia vietnamiensis bacteraemia that occurred 3 months after bilateral lung transplantation for diffuse panbronchiolitis. Persistent bacteraemia developed despite apparent in vitro susceptibility to meropenem. Therefore, antimicrobial therapy was reassessed and modified according to the clinical course rather than susceptibility results alone, which resulted in clearance of bacteraemia. The patient recovered without recurrence during a short-term follow-up. This case highlights an important clinical lesson that antimicrobial susceptibility testing may not reliably predict the treatment response in Burkholderia cepacia complex infections after lung transplantation. Early reassessment of therapy should be considered when bacteraemia persists despite apparently active antimicrobial agents.
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