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Updated: Aug 7, 2026
12:48
Isolation and Analysis of Brain-sequestered Leukocytes from Plasmodium berghei ANKA-infected Mice
Published on: January 2, 2013
Other pathological processes in malaria
Bulletin of the World Health Organization
|January 1, 1974
Summary
Malaria pathology, beyond haemozoin production, involves nonspecific host reactions like inflammatory stasis and vascular obstruction. These physiological-pathological responses are reversible in early stages.
Area of Science:
- Pathology
- Immunology
- Vascular Biology
Background:
- Research post-World War II indicates most malaria pathological processes are nonspecific.
- Host reactions are key to understanding malaria's evolution.
Purpose of the Study:
- To discuss nonspecific host reactions in malaria pathogenesis.
- To elucidate the mechanisms of local obstruction and systemic effects.
Main Methods:
- Review of post-World War II research on malaria pathology.
- Analysis of host responses including inflammatory stasis and vascular plugging.
- Discussion of nonspecific vasomotor effects and coagulation.
Main Results:
- Inflammatory stasis, particularly in the brain, is a basic phenomenon causing local blood flow obstruction.
- "Plugging" by infected erythrocytes contributes to stasis and intravascular schizogony.
- Nonspecific vasomotor effects lead to shock, renal, and hepatic failure.
Conclusions:
- Malaria pathogenesis involves a chain reaction of physiological-pathological host responses.
- These responses, including stasis and vasomotor effects, are reversible in early malaria stages.
- Intravascular coagulation is not considered a primary host response despite consumption coagulopathy.
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