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Circadian Rhythms and Gene Regulation

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...

Circadian Rhythms and Gene Regulation

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...

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Related Experiment Video

Updated: May 22, 2026

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

Circadian clock and cancer.

Zhi-Hao Wei^1,2, Zi-Rui Dong^1,2, An-Shu Li³

¹Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Military Medical Research

|May 21, 2026

Summary

Circadian rhythms regulate key body functions and are linked to cancer. Disrupting these rhythms can promote tumor growth, offering new therapeutic targets for cancer management.

Keywords:

Cancer Chronotherapy Circadian clock DNA damage response Hypoxia signaling Immunity Metabolic reprogramming

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Related Experiment Videos

Last Updated: May 22, 2026

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

Rapid Analysis of Circadian Phenotypes in Arabidopsis Protoplasts Transfected with a Luminescent Clock Reporter

Rapid Analysis of Circadian Phenotypes in Arabidopsis Protoplasts Transfected with a Luminescent Clock Reporter

Published on: September 17, 2016

Area of Science:

Chronobiology
Oncology
Molecular Biology

Background:

Circadian rhythms govern essential physiological processes like sleep, hormone secretion, and metabolism.
These biological rhythms are synchronized by environmental cues, mainly the light-dark cycle.
Disruption of circadian rhythms is increasingly linked to cancer development, progression, and treatment outcomes.

Purpose of the Study:

To systematically review the roles and molecular mechanisms of circadian rhythms in tumor development.
To explore strategies for modulating clock genes in cancer management.
To highlight the potential of circadian rhythm modulation as a novel therapeutic approach.

Main Methods:

Systematic literature review.
Analysis of molecular mechanisms underlying circadian rhythm disruption in cancer.
Evaluation of therapeutic strategies targeting clock genes.

Main Results:

Dysregulation of core clock genes disrupts cellular rhythms, leading to uncontrolled cell proliferation, impaired DNA repair, altered metabolism, and compromised immune surveillance.
Aberrant circadian rhythms are implicated in cancer initiation, progression, and response to therapy.
Behavioral, pharmacological, and gene-editing approaches can modulate clock genes.

Conclusions:

Circadian clock genes play a pivotal role in cancer development.
Modulating circadian rhythms presents promising novel therapeutic strategies for cancer management.
Further research into clinical applications of circadian-based therapies is warranted.