Vascular and autonomic correlates of screening-positive depressive symptom burden in chronic atrophic gastritis: a
Meng Wang1, Shunlei Jiang2, Zixiang Jin3
1Institute of Basic Theory of Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Insights
This study investigates if vascular and autonomic measures can help detect depressive symptoms in chronic atrophic gastritis patients, potentially improving mental health care access.
Area of Science:
- Gastroenterology
- Cardiology
- Psychiatry
Background:
- Depressive symptoms are prevalent in gastroenterology but often undetected.
- Stigma and self-report limitations create a detection gap for mental health care.
- The link between peripheral vascular/autonomic measures and depressive symptoms in this population is understudied.
Purpose of the Study:
- To assess the association between vascular/autonomic measures and depressive symptom burden in chronic atrophic gastritis.
- To determine if these measures offer additional diagnostic information beyond clinical and histological factors.
Main Methods:
- A multicenter observational study involving 450-520 adults with chronic atrophic gastritis.
- Utilizing Doppler ultrasonography, pulse wave velocity, and psychological questionnaires.
- Analyzing associations using multivariable regression and discrimination analyses.
Main Results:
- No participants enrolled; no data collected at submission.
- The study protocol is designed to evaluate the primary and secondary objectives.
Conclusions:
- Findings may guide future research and multidisciplinary care strategies.
- Potential to enhance the detection of depressive symptoms in gastroenterology settings.
Background:
Depressive symptoms are common in gastroenterology practice but often missed due to patient stigma and the limitations of self-report questionnaires. This detection gap limits patient access to necessary mental health care. Although vascular dysfunction has been associated with depressive symptoms, the role of accessible peripheral vascular and autonomic measures in relation to concurrent questionnaire-defined depressive symptom burden in gastroenterology settings remains insufficiently studied. This study aims to evaluate whether vascular and autonomic measures are associated with screening-positive depressive symptom burden in chronic atrophic gastritis and whether they may provide adjunctive information beyond conventional clinical and histological variables.
Methods And Analysis:
This multicenter observational protocol plans to enroll 450-520 adults aged 20-60 years with histologically confirmed chronic atrophic gastritis from four centers in China. The study includes dorsalis pedis artery Doppler ultrasonography, brachial-ankle pulse wave velocity assessment, gastrointestinal and histological evaluation, and standardized psychological questionnaires. The primary analysis examines whether vascular and autonomic measures are associated with concurrent screening-positive depressive symptom burden (PHQ-9 ≥ 10) and whether they provide incremental information beyond clinical and histological variables. Multivariable regression and internally validated discrimination analyses are used. No participants have been enrolled and no data have been collected at the time of submission.
Discussion:
The findings may help inform future validation studies and multidisciplinary assessment strategies in gastroenterology settings.
Conclusion:
This study aims to evaluate whether vascular and autonomic measures are associated with screening-positive depressive symptom burden in chronic atrophic gastritis and whether they may provide adjunctive information beyond conventional clinical and histological variables.
Clinical Trial Registration:
[ClinicalTrials.gov], identifier [NCT07319338].
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