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Bibliometric study on hotspots and trends of immunotherapy for kidney cancer from 2014 to 2024

Qiong Guo1, Zhongbiao Nie1

  • 1Department of Pharmaceutical, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, China.

Translational Andrology and Urology
|May 21, 2026
PubMed
Abstract

Insights

Kidney cancer immunotherapy research has rapidly expanded since 2019, with the USA, China, and Italy leading. Key focuses include established agents and mechanisms, with emerging trends in tumor microenvironment research.

Area of Science:

  • Oncology
  • Immunology
  • Bibliometrics

Background:

  • Kidney cancer, primarily renal cell carcinoma (RCC), poses a significant global health challenge.
  • The treatment of metastatic RCC (mRCC) has seen substantial advancements.
  • Understanding trends in kidney cancer immunotherapy is crucial for advancing patient care.

Purpose of the Study:

  • To systematically analyze the research status, hotspots, and trends in kidney cancer immunotherapy.
  • To integrate findings from scattered studies using bibliometric analysis.
  • To identify key contributors and emerging research areas in the field.

Main Methods:

  • Bibliometric analysis of 5,123 papers from the Web of Science Core Collection (2014-2024).
  • Analysis focused on publications, countries, institutions, authors, co-citations, and keywords.
  • Utilized CiteSpace 5.8.R3 software for data analysis.

Main Results:

  • Research experienced steady growth (2014-2018) followed by rapid expansion (2019-2024), with a 50% increase in publications in 2020.
  • The USA, China, and Italy were top contributing countries; Harvard University and the University of Texas System led institutions.
  • Key contributors included Choueiri TK and Motzer RJ. Dominant keywords were 'renal cell carcinoma,' 'immunotherapy,' 'sunitinib,' and 'nivolumab.'

Conclusions:

  • Kidney cancer immunotherapy research has significantly accelerated since 2019.
  • Current research emphasizes established immunotherapeutic agents and mechanisms.
  • Future research directions are shifting towards the tumor microenvironment, including 'interferon alpha,' 'tumor-infiltrating lymphocytes,' and 'dendritic cells'.
Keywords:
CiteSpaceImmunotherapyWeb of Sciencebibliometric analysiskidney cancer

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