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Tea polyphenols suppress the malignant progression of renal cancer cells by targeting Nosip

Jiao Wang1, Zheng Huang1, Dandan Yang1

  • 1Bengbu Medical University Key Laboratory of Cancer Research and Clinical Laboratory Diagnosis, Bengbu Medical University, Bengbu, China.

Translational Andrology and Urology
|May 21, 2026
PubMed
Abstract

Insights

Nosip acts as an oncogene in renal cell carcinoma (RCC). Tea polyphenols (TPs) suppress RCC progression by downregulating Nosip, offering a potential therapeutic strategy for this cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Renal cell carcinoma (RCC) presents limited treatment options and a poor prognosis, necessitating novel therapeutic strategies.
  • Nosip's role in cell growth regulation, through endothelial nitric oxide synthase (eNOS) activation and erythropoietin receptor ubiquitination, suggests its oncogenic potential in RCC.

Purpose of the Study:

  • To investigate the role of Nosip in renal cell carcinoma (RCC) progression.
  • To evaluate the therapeutic potential of tea polyphenols (TPs) in targeting Nosip for RCC treatment.

Main Methods:

  • Nosip expression was quantified using RT-qPCR and Western blotting.
  • Functional assays (CCK-8, wound healing, Transwell, apoptosis) assessed RCC cell proliferation, migration, invasion, and apoptosis.
  • Bioinformatics analysis utilized The Cancer Genome Atlas Kidney Clear Cell Carcinoma (TCGA-KIRC) dataset.

Main Results:

  • Nosip was significantly upregulated in RCC tissues and cells, promoting proliferation, migration, and invasion.
  • Tea polyphenols (TPs) suppressed RCC cell viability, induced apoptosis, and inhibited clonogenic capacity.
  • TPs downregulated Nosip expression, and Nosip levels modulated the anti-tumor effects of TPs.

Conclusions:

  • Nosip is identified as a proto-oncogene in RCC.
  • TPs suppress RCC progression by directly targeting and downregulating Nosip.
  • Nosip represents a potential therapeutic target, and TPs offer a basis for Nosip-targeted RCC therapy.
Keywords:
NosipRenal cell carcinoma (RCC)metastasisproliferationtea polyphenols (TPs)

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