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Practice guideline on the prevention and treatment of central line-associated bloodstream infection: Part 2 -

, Yan Kang1, Xiangdong Guan2

  • 1Department of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China.

Journal of Intensive Medicine
|May 21, 2026
PubMed

Insights

This updated guideline provides evidence-based recommendations for preventing and diagnosing central line-associated bloodstream infections (CLABSI) in intensive care units (ICUs). It addresses evolving antibiotic resistance and new treatments for better patient outcomes.

Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Evidence-Based Practice

Background:

  • Central line-associated bloodstream infection (CLABSI) is a major healthcare-associated infection in ICUs, increasing mortality and costs.
  • Evolving antibiotic resistance and new antimicrobials necessitate updated clinical management strategies for CLABSI.
  • The previous guideline on intravascular catheter-related infections was from 2007.

Purpose of the Study:

  • To update the clinical management strategies for intravascular catheter-related infections, specifically CLABSI.
  • To provide evidence-based recommendations for the diagnosis and prevention of CLABSI in adult ICU patients.
  • To incorporate recent advancements in CLABSI diagnosis, treatment, and prevention.

Main Methods:

  • Development of the guideline followed the GRADE methodology for evidence assessment.
  • A multidisciplinary working group formulated clinical questions and conducted systematic literature reviews and meta-analyses.
  • Recommendations were refined through expert reviews, meetings, and multiple voting rounds by the CSCCM Standing Committee.

Main Results:

  • The guideline includes 52 recommendations for adult patients with central venous catheters in the ICU.
  • Part 1 focuses on the diagnosis and prevention of CLABSI.
  • Part 2 will address catheter management post-infection and antimicrobial use.

Conclusions:

  • This guideline provides updated strategies for CLABSI diagnosis and prevention based on current evidence.
  • The recommendations aim to improve patient outcomes and reduce the burden of CLABSI in ICUs.
  • The guideline emphasizes a systematic approach to evidence assessment and recommendation development.

Keywords:
Central line-associated bloodstream infectionDiagnosisGuidelinePreventionTreatment

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