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Published on: December 17, 2019
Heterogeneity of Muscularis Macrophages in the Stomach
Gianluca Cipriani1,2, Sihan Ji1,3, Yuanhang Liu4
1Enteric Neuroscience Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota.
Background And Aims:
Macrophages in the muscle layers of the stomach (muscularis macrophages [MMs]) play a crucial role in regulating gastric motility and immune homeostasis by interacting with cells in their shared environment. The lack of knowledge of the subtypes of murine MMs that reside in the stomach limits a comprehensive understanding of their function and their involvement in disease development.
Methods:
In this study, we used single-cell sequencing analysis of CD45+ immune cells and combined it with previously available data to assess the composition of gastric MMs.
Results:
We distinguished different transcriptionally distinct gastric MMs with unique origin.
Conclusion:
Our study provides a fundamental understanding of the gastric tissue MMs heterogeneity.
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