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Related Experiment Video

Updated: May 22, 2026

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

Gut microbiota and disease.

Tariq Iqbal^1,2

¹Microbiome Treatment Centre, IBR West Link Level, 2.72, University of Birmingham, Birmingham, B15 2TT, U.K.

Essays in Biochemistry

|May 21, 2026

Summary

This summary is machine-generated.

The human gut microbiome contains more genetic material than human cells. Its imbalance, or dysbiosis, impacts neurodegenerative diseases, cancer treatment, and metabolism.

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Last Updated: May 22, 2026

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

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Published on: October 15, 2019

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

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Published on: April 6, 2022

Area of Science:

Microbiology
Genetics
Human Physiology

Background:

The human gut microbiome possesses a vast genetic repertoire, exceeding that of the host.
Gut microbiome composition is crucial for various physiological processes.

Purpose of the Study:

To highlight the functional consequences of gut microbiome dysbiosis.
To explore the links between gut microbiome imbalance and specific health conditions.

Main Methods:

Review of recent studies on gut microbiome function.
Analysis of the impact of dysbiosis on neurodegeneration, cancer chemotherapy, and metabolism.

Main Results:

Gut microbiome dysbiosis is linked to neurodegenerative conditions.
Aberrant gut microbial metabolism affects cancer chemotherapy outcomes.
Imbalances in carbohydrate and amino acid metabolism in the gut have wide-ranging consequences.

Conclusions:

The gut microbiome plays a critical role in human health.
Dysbiosis has significant functional consequences across multiple physiological systems.
Further research into gut microbiome modulation is warranted for therapeutic interventions.