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Related Concept Videos

Gastrulation01:56

Gastrulation

Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata will form...

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Updated: May 22, 2026

Longitudinal Intravital Microscopy Using a Mammary Imaging Window with Replaceable Lid
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Looking in the Rear-View Mirror: How Lineage Tracing Experiments Redefined Cell Hierarchy in the Mammary Gland.

Alexandra Van Keymeulen1

  • 1Université Libre de Bruxelles (ULB), Brussels, Belgium. Alexandra.van.keymeulen@ulb.be.

Journal of Mammary Gland Biology and Neoplasia
|May 21, 2026
PubMed
Summary

Lineage tracing studies have revolutionized mammary gland research, revealing new insights into stem cells and cell hierarchy. These findings challenge traditional models of mammary epithelial organization and differentiation.

Keywords:
BreastCell fateCell hierarchyFluorescent proteinLineage tracingMammary glandMammosphereMultipotencyTransplantationUnipotency

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Last Updated: May 22, 2026

Longitudinal Intravital Microscopy Using a Mammary Imaging Window with Replaceable Lid
10:53

Longitudinal Intravital Microscopy Using a Mammary Imaging Window with Replaceable Lid

Published on: January 20, 2022

Intravital Subcellular Microscopy of the Mammary Gland
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Published on: June 24, 2022

Generation of Mosaic Mammary Organoids by Differential Trypsinization
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Published on: March 11, 2020

Area of Science:

  • Developmental Biology
  • Stem Cell Biology
  • Cell Biology

Background:

  • The mammary gland's cell hierarchy has been a long-standing research focus.
  • Understanding stem cells and their differentiation is crucial for mammary gland biology.

Purpose of the Study:

  • To review key advances in mammary gland research using lineage tracing.
  • To highlight paradigm shifts in understanding mammary epithelial organization.

Main Methods:

  • Review of lineage tracing studies in mammary gland research.
  • Analysis of how these studies have reshaped understanding of cell hierarchy.

Main Results:

  • Lineage tracing has profoundly reshaped understanding of mammary epithelial organization.
  • Traditional models of cell hierarchy and terminal differentiation have been challenged.

Conclusions:

  • Lineage tracing is a powerful tool for dissecting mammary gland development.
  • Current models of mammary gland cell hierarchy require revision based on lineage tracing data.